This paper recounts the approach adopted in this research for the development of a framework and indicators designed to measure the impact of health research on the health sector of Vietnam. For this purpose, consultations were carried out withnational and international agencies, key challenges in the development of the methodology were identified and various requirements were established. The proposed outcomes framework encompasses methodological guidelines, definitions of key concepts, the key health research effects identified by different stakeholdersand the concerns raised by each stakeholder group. Five categories of health research benefits were established on the basis of the range of effects from such scholarship, information sources and related issues. The analysis of issues suggested the need to measureboth impact and performance, with these measurements revolving aroundresearchsuccess and effects that encourage funding agencies to continue supporting health research for knowledge development.