RESEARCH PAPER
Analysis of Spectral Data of the Chemical Constituents from the Leaves of Jasminum grandiflorum L., Achyranthes aspera L. and Tinospora cordifolia (Willd.) Miers
Shahnaz Sultana 1, 2,  
Mohammed Ali 1  
,  
 
 
More details
Hide details
1
Phytochemistry Research Laboratory, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi - 110 062, INDIA
2
Present address: College of Pharmacy, Jazan University, Jazan, SAUDI ARABIA
3
Department of Pharmacy, Hindu Pharmacy College, Sonipat – 131 001, INDIA
Publish date: 2018-07-14
 
Eurasian J Anal Chem 2018;13(5):em43
KEYWORDS:
ABSTRACT:
Jasminum grandiflorum L. (Oleaceae) is used to relieve coughs, depression, dizziness, eye diseases, facial paralysis, general debility, fevers, headache, psoriasis, sciatica, skin diseases and vertigo. Achyranthes aspera L. (Amaranthaceae) is utilized to treat anorexia, ascites, respiratory problems, kidney, brain and skin diseases, cholera, convulsions, diabetes, fistula, hysteria, insect bites, malaria, night blindness, obesity, piles, snake bites, stomach disorders, swellings, tooth aches, tumors and wounds. Tinospora cordifolia (Willd.) Miers (Menispermaceae) is effective to alleviate anemia, debility, diabetes, diarrhea, dysentery, dyspepsia, fevers, jaundice, rheumatism, urinary and skin diseases, scorpion stings and snake bites. The air-dried plant leaves were exhaustively extracted with methanol individually in a Soxhlet apparatus. The concentrated methanol extracts were adsorbed on silica gel for column and chromatographed over silica gel column separately. The columns were eluted with petroleum ether, chloroform and methanol successively to isolate the phytoconstituents. Phytochemical investigation of the leaves of J. grandiflorum afforded glyceryl behenate (2,3-dihydroxypropyl docosanoate, 1), glycerol cerotate (2,3-dihydroxypropyl 1-hexacosanoate, 2), cerotyl O-β-D-diarabinoside (n-hexacosanoyl-O-β-D- arabinopyranosyl-(2ʹ→1″)-O-β-D- arabinopyranoside / cerotyl O-β-D-arabinopyranosyl-(2ʹ→1ʹʹ)-O-β-D-arabinopyranoside, 3), stearyl-O-α-D-triglucoside (stearyl glucopyranosyl-(6′→1′′)-O-α-D- glucopyranosyl-(6′′→1′′′)-O-α-D- glucopyranoside, 4) and behenyl-O-α-D-glucopyranosyl-(6’→1″)-O-α-D-glucopyranosyl-(6’′→1″′)-O-α-D-glucopyranoside, 5). The leaves of A. aspera and T. cordifolia furnished a new diterpenoid ester aromadendr-10(14)-en-15-olyl (E)-ferulate 6) and an aromatic ester phenyl ethyl behenate 7), respectively. The structures of these phytoconstituents have been established on the basis of spectral data analysis and glycosidic and phenolic chemical reactions.
 
REFERENCES (48):
1. Anonymous. The Wealth of India. A Dictionary of Indian Raw Materials and Industrial Products. Publication & Information Directorate, CSIR, New Delhi. 2004:284-88.
2. Sharma PC, Yelne MB and Dennis TJ. Database on Medicinal Plants used in Ayurveda. New Delhi: Central Council for Research in Ayurveda and Siddha. 2005;3:332-345.
3. Kirtikar KR, Basu BD. Indian Medicinal Plants. L M Basu, Allahabad. 1989:1522-1524.
4. Warrier PK, Nambiar VPK, Ramankutty. Indian Medicinal Plants- a Compendium of 500 Species. Orient Longman Pvt Ltd, Chennai. 2004;3:249-253.
5. Sandeep, Paarakh PM. Jasminum grandiflorum Linn. (chameli): ethnobotany, phytochemistry and pharmacology – a review, Pharmacologyonline. 2009;2:586-595.
6. Mittal A, Sardana S, Pandey A. Experimental wound healing aspects of Jasminum grandiflorum Linn: a preclinical study. African Journal of Traditional, Complementary and Alternative Medicines. 2015;12(3):135-142. https://doi.org/10.4314/ajtcam....
7. Mittal A, Sardana S, Pandey A. Phytopharmacological profile of Jasminum grandiflorum Linn. (Oleaceae). Chinese Journal of Integrative Medicine. 2016;22(4):311-320. https://doi.org/10.1007/s11655....
8. Elumalai S, Murugesan R, Chinnasamy N, Prabhakaran M, Baskaran S. Essential oil analysis of FT-IR and GC-MS studies of Jasminum grandiflorum, Jasminum sambac and Polianthus tuberosa flowers. Biomedical & Pharmacology Journal. 2010;3(1):63-72.
9. Ray H, Majumdar S, Biswas SP, Das A, Ghosh TK, Ghosh A. Characterization of the volatile aroma compounds from the concrete and jasmine flowers grown in India. Chemical Engineering Transactions. 2014;40:265–270. https://doi.org/10.3303/CET144....
10. Zhao GQ, Xia JJ, Dong JX. Glycosides from flowers of Jasminum officinale L. var. grandiflorum. Yao Xue Xue Bao. 2007;42(10):1066–1069. PMID: 18229614.
  Pubmed
11. Zhao GQ, Dong JX. Triterpenoid saponin from flower bud of Jasminum officinale var. grandiflorum. Zhongguo Zhong Yao Za Zhi. 2008a;33(1):38-42. PMID: 18338617.
  Pubmed
12. Zhao GQ, Yin ZF, Dong JX. A new secoiridoid from the flowers of Jasminum grandiflorum. Yao Xue Xue Bao. 2008b;43(3):513-517.
13. Sadhu SK, Khan MS, Ohtsuki T, Ishibashi M. Secoiridoid components from Jasminum grandiflorum. Phytochemistry. 2007;68(13):1718-1721. https://doi.org/10.1016/j.phyt....
14. Anonymous. The Wealth of India-Raw Materials, Council of Scientific & Industrial Research, New Delhi. 2005:55-57.
15. Kirtikar KR, Basu BS. Indian Medicinal Plants. 2nd Edition. Revised by Blatter E, Caius JF, Mahaskar KS. Published by Mohan Basu Lalit, Allhabhad. 1984;3:2068.
16. Londonkar R, Reddy VC, Kumar KA. Potential antibacterial and antifungal activity of Achyranthes aspera L. Recent Research in Science and Technology. 2011;3(4):53-57.
17. Srivastav S, Singh P , Mishra G, Jha KK, Khosa RL. Achyranthes aspera - An important medicinal plant: a review. Journal of Natural Product and Plant Resources. 2011;1(1):1-14.
18. Vijayaraj R, Vidhya R. Biological activity of Achyranthes aspera Linn. - a review. Asian Journal of Biochemical and Pharmaceutical Research. 2016;6(1):86–93.
19. Ali M. Chemical investigation of Achyranthes aspera Linn. Oriental Journal of Chemistry. 1993;9:84- 85.
20. Misra TN, Singh RS, Pandey HS, Prasad C, Singh S. Isolation and characterization of two new compounds from Achyranthes aspera Linn. Indian Journal of Chemistry. 1996;35B:637-639.
21. Sharma SK, Vasudeva N, Ali M. A new aliphatic acid from Achyranthes aspera Linn. roots, Indian Journal of Chemistry. 2009;48B(8):1164-1169.
22. Ali MK, Rahman MA, Quader MA. Sterols from the leaves of Apang (Achyranthes aspera). Dhaka University Journal of Science. 2004;52:1-6.
23. Michl G, Abebe D, Bucar F, Debella A, Kunert O, Schmid MG, Mulatu E. New triterpenoid saponin from Achyranthes aspera Linn. Haslinger. Helvetica Chimica Acta. 2000;83(2):359-363. https://doi.org/10.1002/(SICI)...<359::AID-HLCA359>3.0.CO;2-7.
24. Rishikesh, Rahman MM, Goffar MR, Al- Mamun MR, Dutta PR, Al- Maruf MA. Phytochemical and Pharmacological Investigation of Achyranthes aspera Linn. Scholars Academic Journal of Pharmacy. 2013;2(2):74-80.
25. Laddha KS, Ghosh D. Extraction, isolation and purification of 20-hydroxyecdysone from Achyranthes aspera and its characterization by DSC, UV, IR. Natural Products. 2005;1(1-2):1-4.
26. Rameswar RD. Essential oil constituents of Achyranthes aspera leaves. Indian Perfumer. 2007;51(1):33-34.
27. Aziz MA, Rahman MM, Mondal AK, Muslim T, Rahman MA, Quader MA. 3-Acetoxy-6-benzoyloxyapangamide from Achyranthes aspera. Dhaka University Journal of Pharmarmaceutical Sciences. 2005;4(2):113-116.
28. Chauhan AS, Rawat GS, Singh CP. Phytochemical study of Achyranthes aspera Linn. Asian Journal of Chemistry. 2002;14(2):1059-1061.
29. Rashmi, Dayal R. Fatty acid composition of Achyranthes aspera seed oil. Journal of Oil Technologist’s Association of India. 2003:53 -54.
30. Kirtikar KR, Basu BD. Indian medicinal plants, India, M/S Bishen Singh and Mahendra Pal Singh, Dehradun. 1995:75-80.
31. Anonymous. The Wealth of India, A dictionary of Indian raw materials and industrial products. National Institute of Science Communication and Information Resources, CSIR, New Delhi. 2004;10:251.
32. Quattrocchi U. CRC World Dictionary of Medicinal and Poisonous Plants: Common Names, Scientific Names, Eponyms, Synonyms and Etymology. CRC Press, Boca Raton, Florida. 2012:3743. https://doi.org/10.1201/b16504.
33. Jeyachandran R, Xavier TF, Anand SP. Antibacterial activity of stem extracts of Tinospora cordifolia (Willd) Hook. f & Thomson. Anc Science Life. 2003;23(1):40-43.
34. Sinha K, Mishra NP, Singh J, Khanuja SPS. Tinospora cordifolia (Guduchi), a reservoir plant for therapeutic applications: a review. Indian Journal of Traditional Knowledge. 2004;3(3):257-270.
35. Puranik N, Kammar KF, Devi S. Anti-diabetic activity of Tinospora cordifolia (Willd.) in streptozotocin diabetic rats; does it act like sulfonylureas? Turkish Journal of Medical Science. 2010;40(2):265-270.
36. Patel A, Bigoniya P, Singh CS, Patel NS. Radioprotective and cytoprotective activity of Tinospora cordifolia stem enriched extract containing cordifolioside-A. Indian Journal of Pharmacology. 2013;45(3):237–243. https://doi.org/10.4103/0253-7....
37. Shanthi V, Nelson R. Anitbacterial activity of Tinospora cordifolia (Willd) Hook. f. Thoms on urinary tract pathogens. International Journal of Current Microbiology Applied Sciences. 2013;2(6):190-194.
38. Joshi G, Kaur R. Tinospora cordifolia: A phytopharmacological review. International Journal of Pharmaceutical Science and Research. 2016;7(3):890-897. https://doi.org/10.13040/IJPSR....
39. Alsuhaibani S, Khan MA. Immune-stimulatory and therapeutic activity of Tinospora cordifolia: double-edged sword against Salmonellosis. Journal of Immunology Research, Article ID 1787803, 9 pages. 2017. https://doi.org/10.1155/2017/1....
40. Prakash R, Sandhya E, Ramya N, Dhivya R, Priyadarshini M, Sakthi Priya B. Neuroprotective activity of ethanolic extract of Tinospora cordifolia on LPS induced neuroinflammation. Translational Biomedicine. 2017;8(4):135, 1-9. https://doi.org/10.21767/2172-....
41. Gangan VD, Pradhan P, Sipahimalani AT, Bhave VG, Patil KA. N-Feruloyltyramine from Tinospora cordifolia. Indian Journal of Chemistry. 1997;36B:837-849.
42. Maurya R, Manhas LR, Gupta P, Mishra PK, Singh G, Yadav PP. Amritosides A, B, C and D: clerodane furano diterpene glucosides from Tinospora cordifolia. Phytochemistry. 2004;65(14):2051-2055. https://doi.org/10.1016/j.phyt....
43. Sipahimalani AT, Noerr H, Wagner H. Phenylpropanoid glycosides and tetrahydrofuranlignan glycosides from the adaptogenic plant drugs Tinospora cordifolia and Drypetes roxburghii. Planta Medica. 1994;60(6):596-597. https://doi.org/10.1055/s-2006....
44. Pathak AK, Agarwal PK, Jain DC, Sharma RP, Howarth OW. NMR studies of 20β-hydroxyecdysone, a steroid isolated from Tinospora cordifolia. Indian Journal of Chemistry. 1995;34B:674-676.
45. Ahmad F, Ali M, Alam P. New phytoconstituents from the stem bark of Tinospora cordifolia Miers. Natural Product Research. 2010;24(10):926-934. https://doi.org/10.1080/147864....
46. Singh D, Chaudhuri PK. Chemistry and pharmacology of Tinospora cordifolia. Natural Product Communications. 2017;12:299-308.
47. Sultana S, Ali M, Jameel M. Phytochemical investigation and isolation of new compounds from the stems of Tinospora cordifolia Miers. Trends in Phytochemical Research. 2017;1(2):83-92.
48. Al Omari MMH, Qinna NA, Rashid IS, Al-Sou’od K. Prasugrel hydrochloride. Profiles of Drug Substances, Excipients andRelated Mehodology. 2015;40:195-320. https://doi.org/10.1016/bs.pod....
eISSN:1306-3057