RESEARCH PAPER
Application of TLC-Densitometric method for simultaneous determination of sacubitril and valsartan in their newly approved pharmaceutical formulation
| 1 | Analytical Chemistry, Al-Azhar University, Egypt |
CORRESPONDING AUTHOR
Publication date: 2019-02-07
Eurasian J Anal Chem 2018;13(6):em
KEYWORDS
TOPICS
ABSTRACT
Background:
Entresto® (Sacubitril/valsartan) is a recently approved oral drug for the treatment of symptomatic chronic heart failure
Material and methods:
The TLC-densitometric separation process has been achieved on pre-coated silica gel (60 GF254) plates using toluene–ethyl acetate–methanol mixture (4: 4: 2, by volume) as a developing system.
Results:
The well separated bands have been quantified densitometrically at 260 nm. Calibration graphs were found to be linear over a concentration range of 0.1–0.6 μg band-1 for two drugs.
Conclusions:
The proposed method has been successfully applied to the analysis of sacubitril and valsartan in Entresto® tablets.
Entresto® (Sacubitril/valsartan) is a recently approved oral drug for the treatment of symptomatic chronic heart failure
Material and methods:
The TLC-densitometric separation process has been achieved on pre-coated silica gel (60 GF254) plates using toluene–ethyl acetate–methanol mixture (4: 4: 2, by volume) as a developing system.
Results:
The well separated bands have been quantified densitometrically at 260 nm. Calibration graphs were found to be linear over a concentration range of 0.1–0.6 μg band-1 for two drugs.
Conclusions:
The proposed method has been successfully applied to the analysis of sacubitril and valsartan in Entresto® tablets.
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