0.60
CiteScore
0.186
SJR
0.447
SNIP
 
 

Determination of albendazole in the presence of its alkaline degradation product using TLC-densitometric and chemometric methods: A comparative study

 
1
Al Azhar University
2
Al-azhar University
3
Al Azhar Univ, Fac Pharm, Dept Pharmaceut Analyt Chem, Cairo 11751, Egypt.
Eurasian J Anal Chem 2017;12(4)
Publish date: 2017-01-04
KEYWORDS:
TOPICS:
ABSTRACT:
Background:
Albendazole, is a broad spectrum anthelmintic. It is used for the treatment of Threadworm, Hookworm and Tape-worm

Material and methods:
Method A is a densitometric one, after separation on silica gel plate using dichloromethane: methanol (90:10 v/v) as a mobile phase and the spots were scanned at 232 nm. Methods B, C and D, chemometric-assisted methods, including classical least squares (CLS), principal component regression (PCR) and partial least squares

Results:
Method A, Beer’s law was obeyed over the concentration range of 1–5 μg/spot. Methods B, C and D, albendazole was analyzed with mean accuracy of 99.940.159, 99.930.159 and 99.930.158 for CLS, PCR and PLS, respectively. A comparative study between the methods was done showing the advantages and the disadvantages of each method.

Conclusions:
These methods are suitable as stability indicating methods for the simultaneous determination of albendazole in the presence of its alkaline degradation product either in bulk powder or in pharmaceutical formulations.

CORRESPONDING AUTHOR:
Mohamed S. Emara   
Al Azhar Univ, Fac Pharm, Dept Pharmaceut Analyt Chem, Cairo 11751, Egypt., Nasr City, Cairo, Egypt, 11751 Cairo, Egypt
Copy url
Share
 
 
eISSN:1306-3057