Direct Determination of Captopril Using Electrogenerated Halogens for Pharmaceuticals Quality Control
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Analytical Chemistry Department, A.M. Butlerov Chemical Institute, Kazan State University, Kremlyevskaya, 18, Kazan, Russia
Guzel K. Ziyatdinova   

Department of Analytical Chemistry, А.М. Butlerov Chemical Institute, Kazan State University, Kremlyevskaya, 18, 420008 Kazan, Russia
Online publish date: 2007-06-15
Publish date: 2007-06-15
Eurasian J Anal Chem 2007;2(2):84–92
Simple, rapid, accurate and inexpensive coulometric method for captopril determination using electrochemically generated halogens as titrants is proposed. The stoichiometric coefficients of the reactions are 1:3, 1:3 and 1:1, for chlorine, bromine and iodine, respectively. Procedure for direct determination of captopril in pharmaceuticals has been developed with an RSD of 0.01-0.04. The data were compared with the results obtained by anodic adsorptive stripping voltammetry. Good agreement of the data obtained allows to propose coulometric determination for pharmaceuticals quality control.
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