Direct Determination of Captopril Using Electrogenerated Halogens for Pharmaceuticals Quality Control
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Analytical Chemistry Department, A.M. Butlerov Chemical Institute, Kazan State University, Kremlyevskaya, 18, Kazan, Russia
Guzel K. Ziyatdinova   

Department of Analytical Chemistry, А.М. Butlerov Chemical Institute, Kazan State University, Kremlyevskaya, 18, 420008 Kazan, Russia
Online publication date: 2007-06-15
Publication date: 2007-06-15
Eurasian J Anal Chem 2007;2(2):84–92
Simple, rapid, accurate and inexpensive coulometric method for captopril determination using electrochemically generated halogens as titrants is proposed. The stoichiometric coefficients of the reactions are 1:3, 1:3 and 1:1, for chlorine, bromine and iodine, respectively. Procedure for direct determination of captopril in pharmaceuticals has been developed with an RSD of 0.01-0.04. The data were compared with the results obtained by anodic adsorptive stripping voltammetry. Good agreement of the data obtained allows to propose coulometric determination for pharmaceuticals quality control.
Parfitt K (1999) Martindale: The Complete Drug Reference, 32nd Edition, The Pharmaceutical Press, Massachusetts.
Aykin N, Neal R, Yusof M and Ercal N (2001) Determination of captopril in biological samples by HPLC with ThioGloTM3 derivatization. Biomed Chromatogr 15: 427.
Pimenta A M, Araujo A N and Montenegro M C B S M (2001) Sequential injection analysis of captopril based on colorimetric and potentiometric detection. Anal Chim Acta 438: 31.
Mirza T and Tan H S I (2001) Determination of captopril in pharmaceutical tablets by anion-exchange HPLC using indirect photometric detection; a study in systematic method development. J Pharm Biomed Anal 25: 39.
Bahmei M, Khosravi A, Zamiri C, Massoumi A and Mahmoudian M (1997) Determination of captopril in human serum by high performance liquid chromatography using solid-phase extraction. J Pharm Biomed Anal 15: 1181.
Sypniewski S and Bald E (1996) Determination of captopril and its disulfides in whole human blood and urine by high-performance liquid chromatography with ultraviolet detection and precolumn derivatization. J Chromatogr A 729: 335.
Arroyo C, Lopez-Callul C, Garcia-Capdevila L, Gich I, Barbanoj M and Bonal J (1997) Determination of captopril in plasma by high-performance liquid chromatography for pharmacokinetic studies. J Chromatogr B 668: 339.
Kok R J, Visser J, Moolenaar F, De Zeeuw D and Meijer D K F (1997) Bioanalysis of captopril: two sensitive high-performance liquid chromatographic methods with pre- or postcolumn fluorescent labeling. J Chromatogr B 693: 181.
Karlicek R and Solich P (1998) Flow-injection spectrophotometric determination of captopril using on-line solid phase extraction. Pharmazie 53: 549.
Tzanavaras P D, Themelis D G, Economou A and Theodoridis G (2002) Reversed flowinjection manifold for the spectrophotometric determination of captopril based on its inhibitory effect on the Co(II)–2,2′-dipyridyl-2-pyridylhydrazone complex formation. Talanta 57: 575.
Imai K, Toyo’oka T and Watanabe Y (1983) A novel fluorogenic reagent for thiols: Ammonium 7-fluorobenzo-2-oxa-1,3-diazole-4-sulfonate. Anal. Biochem. 128: 471.
Zhang Z D, Baeyens W R G, Zhang X R and Van der Weken G (1996) Chemiluminescence flow-injection analysis of captopril applying a sensitized rhodamine 6G method. J Pharm Biomed Anal 14: 939.
Passamonti P, Bartocci V and Pucciarelli F (1987) Determination of captopril using adsorptive cathodic differential pulse stripping voltammetry. J Electroanal Chem Interf Electrochem 230: 99.
Sarna K and Fijalek Z (1997) Polarographic and voltammetric determination of captopril and captopril-disulphide using a control grow mercury drop electrode. Chem Anal 42: 863.
Stefan R I, Van Staden J F and Aboul-Enein H Y (2000) Amperometric biosensors/sequential injection analysis system for simultaneous determination of S- and R-captopril. Biosens Biolectron 15: 1.
Palomeque M E and Band B S F (2002) Flow injection biamperometric determination of captopril. J Pharm Biomed Anal 30:547.
Li B, Zhang Z and Wu M (2001) Flow-injection chemiluminescence determination of captopril using on-line electrogenerated silver(I) as the oxidant. Microchem J 70: 85.
El-Shabrawy Y, El-Enany N and Salem K (2004) Sensitive kinetic spectrophotometric determination of captopril and ethamsylate in pharmaceutical preparations and biological fluids. Il Farmaco 59: 803.
Salem I I, Saif W A, Jmeian Y and Al Tamimi J I (2004) A selective and rapid method for the quantification of captopril in human plasma using liquid chromatography/selected reaction monitoring mass spectrometry. J Pharm Biomed Anal 37: 1073.
Ribeiro P R da S, Santini A O, Pezza H R and Pezza L (2003) Potentiometric determination of captopril in pharmaceutical formulations. Eclet Quim 28: 39.
Siangproh W, Ngamukot P and Chailapakul O (2003) Electrochemical determination of captopril at boron-doped diamond thin film electrode applied to a flow injection system. Sens Actuat B 91: 60.
Shahrokhian S, Karimi M and Khajehsharifi H (2005) Carbon-paste electrode modified with cobalt-5-nitrolsalophen as a sensitive voltammetric sensor for detection of captopril. Sens Actuat B 109: 278.
Ioannides X, Economou A and Voulgaropoulos A (2003) A study of the determination of the hypertensive drug captopril by square wave cathodic adsorptive stripping voltammetry. J Pharm Biomed Anal 33: 309.
Ghandour M A, Kasim E A, El-Haty M T and Ahmed M M (2002) Cathodic stripping voltammetry of the antihypertensive drug captopril in both aqueous and biological media. Anal Lett 35: 239.
Abdullin I F and Budnikov G K (1998) Coulometric analysis of organic compounds. Zavod Lab Diagn Mater 64: 1.
Ziyatdinova G K, Budnikov H C and Pogorel’tzev V I (2006) Determination of captopril in pharmaceutical forms by stripping voltammetry. J Anal Chem 61: 798.