The leaders in the creation of innovations in European Union countries, taking into account innovative enterprises, are Germany, Luxembourg, Belgium, Ireland, United Kingdom and Austria. The aim of the article is to answer the question: what is the relation between the European Innovation Scoreboard and entrepreneurial framework conditions based on the GEM and additionally innovative enterprises divided into product, process, organizational and marketing? This article provides a comparative assessment of innovation performance of the EU Member States in 2016 through the prism of factors determining the level of entrepreneurial activity based on the Global Entrepreneurship Monitor (GEM) model of economic development. The article presents 28 EU countries as leader, strong, moderate and modest countries in innovations and entrepreneurship.