Green and Efficient Synthesis of a Novel Series of Indeno-Fused Pyrido [2,3-d] Pyrimidines Using Choline Hydroxide as Eco-Friendly Catalyst in Water
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Islamic Azad University (Yazd Branch), IRAN
Online publish date: 2017-10-09
Publish date: 2017-10-09
Eurasian J Anal Chem 2017;12(Interdisciplinary Perspective on Sciences 7b):1339–1345
A series of 13 aryl indeno[2’,1’:5,6]pyrido[2,3-d]pyrimidine-2,4,6-(3H,5H,11H)-triones, 8 of which are new, were synthesized regioselectively in high yields by a three-component reaction of 1,3-indanedione, an araldehyde and 6-aminopyrimidin-2,4(1H,3H)-dione in the presence of choline hydroxide as catalyst in water. The reaction conditions were mild and did not require additional catalysts. Given the inexpensive, nontoxic, and recyclable nature of the choline hydroxide, these reaction conditions are simple to carry out and environmentally friendly.
Mohammad Hossein Mosslemin   
Department of Chemistry, Yazd Branch, Islamic Azad University, PO Box 89195-155, Yazd, Iran
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