Indirect Electrothermal Atomization Atomic Absorption Spectrometric Determination of the Drug Desferrioxamine in Some Pharmaceutical Preparations Using Vanadium (V) as a Mediating Element
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Department of Chemistry, College of Science for Women, University of Baghdad, Jadiryia, Baghdad, Iraq
Department of Chemistry, College of Science, University of Baghdad, Jadiryia, Baghdad, Iraq
Zuhair A-A. Khammas   

Department of Chemistry, College of Science for Women, University of Baghdad, Jadiryia, Baghdad, Iraq
Publication date: 2017-10-06
Eurasian J Anal Chem 2009;4(3):257–269
A method has been developed for the determination of the drug Desferrioxamine (DFOM) in some pharmaceuticals using indirect electrothermal atomic absorption spectrometry (ETAAS) supplied with zirconium-coated graphite tube and V (V) as a mediating metal. Vanadium (V) forms a chelate complex with (DFOM) at pH range 1-1.5 which could be extracted with benzyl alcohol under certain experimental conditions. Aliquots of the extracts are injected into the coated graphite furnace and the atomic absorption signals are measured. A standard calibration graph was constructed and from which several parameters and figures of merit were found, such as: linear range (0.5-19 μg mL–1) of DFOM, relative standard deviation (1.44-1.68%); low of detection (0.12 μg mL–1)sensitivity. (424.2 pg), recovery %( 101.57± 0.147) and relative error (1.57%). The mole ratio method has been used to determine the structure of chelate DFOM: V (V) and found to be 1:1. The developed procedure is applied to analyze DFOM in several commercially available pharmaceuticals using direct and standard additions methods and results are comparable. All statistical calculations are implemented via a Minitab software version 11.
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