Investigation on the in Vitro Biotrans Formation of NCE Using LC-MS/MS
More details
Hide details
Publication date: 2019-05-23
Eurasian J Anal Chem 2019;14(2):emEJAC191035
With the dramatic increase in the number of new chemical entities (NCEs) arising from combinatorial chemistry and high-throughput processes, novel bioanalytical techniques are required for the rapid determination of the metabolites of these NCEs. Knowledge of the metabolic sites of the NCEs in early drug discovery is essential for selecting compounds with favorable pharmacokinetic. In development, elucidation of biotransformation pathways of a drug candidate it is important to understand its physiological effects. Liquid chromatography(LC) coupled with atmospheric pressure ionization (API) MS has now become the most powerful tool for the rapid detection, structure elucidation, and quantification of drug-derived material within various biological fluids