RESEARCH PAPER
Investigation on the in Vitro Biotrans Formation of NCE Using LC-MS/MS
 
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Publish date: 2019-05-23
 
Eurasian J Anal Chem 2019;14(2):emEJAC191035
ABSTRACT
With the dramatic increase in the number of new chemical entities (NCEs) arising from combinatorial chemistry and high-throughput processes, novel bioanalytical techniques are required for the rapid determination of the metabolites of these NCEs. Knowledge of the metabolic sites of the NCEs in early drug discovery is essential for selecting compounds with favorable pharmacokinetic. In development, elucidation of biotransformation pathways of a drug candidate it is important to understand its physiological effects. Liquid chromatography(LC) coupled with atmospheric pressure ionization (API) MS has now become the most powerful tool for the rapid detection, structure elucidation, and quantification of drug-derived material within various biological fluids
eISSN:1306-3057