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Methods for the Estimation of Ellagic Acid and Curcumin in Antidiabetic Herbal Formulations – A Review

Megha Ashesh Shah 1  ,  
Harsha Patel 2,  
 
1
Shri G. M. Bilakhia College of Pharmacy, INDIA
2
Shri Sarvajanik Pharmacy College, INDIA
3
Shree Dhanvantary Pharmacy College, INDIA
Eurasian J Anal Chem 2017;12(4):295–311
Online publish date: 2016-12-26
Publish date: 2016-12-26
KEYWORDS:
TOPICS:
ABSTRACT:
Diabetes mellitus is the most common endocrine disorder, affecting 200 million worldwide. Despite the use of advanced synthetic drugs for the treatment, use of herbal remedies is gaining higher importance because of synthetic drugs have drawbacks and limitations. Antidiabetic herbal formulations (AHF) are considered to be more effective for the management of diabetes. Various Antidiabetic Herbal formulations are available in market which contain different constituents whose combine effect is necessary for the activity. Here, 2 constituents are selected i.e. Ellagic acid and Curcumin. An extensive survey of the literature published in various analytical and pharmaceutical chemistry related journals has been conducted and the instrumental analytical methods which were developed and used for determination of Ellagic acid and Curcumin as single or combination with other Herbal constituents in bulk drugs, formulations and biological fluids have been reviewed. This review covers the time period from 1972 to 2015 during which 48 analytical methods including spectrophotometric methods like U spectroscopy Chromatographic methods including HPLC, HPTLC and miscellaneous methods were reported.
CORRESPONDING AUTHOR:
Megha Ashesh Shah   
ROFEL, Shri G.M. Bilakhia College of Pharmacy, India
 
REFERENCES:
1. National diabetes Services scheme, diabetes information sheet, Diabetes Australia, 1-37.
2. WHO. (1998). Guidelines for the Appropriate Use of Herbal Medicines. WHO Regional Publications, Western Pacific Series WHO Regional office for the Western Pacific, Manila, 3, 35. (http://apps.who.int/medicinedocs/en/d/Jh2945e/).
3. WHO. (1998). Quality Control Methods for Herbal Materials Updated edition of Quality control methods for medicinal plant materials. World Health Organization, Geneva, 1-9.
4. WHO. (1999). WHO Monographs on Selected Medicinal Plants, World Health Organization, Geneva, 1, 34.
5. Lianga, Y. Z., Xie, P., & Chang, K. (2004). Quality control of herbal medicines. Journal of Chromatography B, 812, 50-53.
6. Klier, B. (2007). Current Problems with Identification of Herbal Drugs. The Nature Network Phyto Lab, 5, 1- 23.
7. WHO. (2004). Guidelines on Safety Monitoring Of Herbal Medicines In Pharmacovigilance Systems, World Health Organization Geneva, 1-5.
8. Liu, S. H., Wei, C. B., Zang, X. P., & Liu, Y. G. (2011). Determination of Free Ellagic Acid Content in Guava Leaves by HPLC. Food Science, 32(8), 252-254.
9. Liu, Z. P. (2012). Determination of Ellagic Acid in Pomegranate Seeds by RP-HPLC. Food Science, 33(18), 220-222.
10. Renatanowak. (2006). Determination of ellagic acid in pseudo fruits Of some species of roses. ActaPoloniaePharmaceutica and Drug research, 63(4), 289-292.
11. PharkphoomPanichayupakarananta, AtcharapornIssuriya, AnusakSirikatitham, & WeiWang. (2010). Antioxidant Assay-Guided Purification and LC Determination of Ellagic Acid in Pomegranate Peel. Journal of Chromatographic Science, 48, 456-459.
12. Häkkinen, S. H., Kärenlampi, S. O., & Mykkänen H. M. (2000). Ellagic acid content in berries, Influence of domestic processing and storage. European Food Research and Technology, 212(1), 75-80.
13. Patel, M. G., Patel, V. R., Patel, R. K. (2010). Development and Validation of Improved RP-HPLC method for Identification and Estimation of Ellagic and Gallic acid in Triphalachurna. International Journal of Chem Tech Research. 2(3), 1486-1493.
14. Charrier, B., Marques, M., & Haluk, J. P. (1992). HPLC Analysis of Gallic and Ellagic Acids in European Oakwood (Quercusrobur L.) and Eucalyptus (Eucalyptus globulus). Holzforschung, 46, 87-89.
15. Patel, V. R., & Patel, R. K. (2013). Simultaneous Analysis and Quantification of Markers of ManjisthadiChurna Using High Performance Thin Layer Chromatography. Indian J Pharm Sci. 75(1), 6–109.
16. Krishna, N., Meyyanathan, N., & Suresh, B. (2012). Analysis of Ellagic acid in Fresh and processed fruit products by High Performance Thin Layer Chromatography. IRJP, 3(7), 201-204.
17. Bagul, M. S., & Rajani, M. (2006). Quantification of Ellagic acid, Gallic acid and Picroside-I from Phalatrikadikvathachurna by HPTLC. Journal of Natural remedies, 6(1), 53-61.
18. Jeganathan, N. S., & Kannan, K. (2008). HPTLC Method for Estimation of Ellagic Acid and Gallic Acid in Triphalachuranam Formulations. Research Journal of Phytochemistry. 2(1), 1-5.
19. Tiwari, P., & Patel, R. K. (2012). Quantification of Gallic acid and Ellagic acid in Arjunarishta by validtaed HPTLC densitometry. IJPSR. 3(7), 2215-2223.
20. Patel, S. G., & Patel, J. K. (2012). Comparison & Quantification of Marker compound of TriphalaGuggulu by using HPTLC method. Am. J. Pharmtech Res., 2(4), 999-1013.
21. Guddadarangavvanahally, K. Jayaprakasha, LingamulluJagan M. R., & Kunnumpurath K. S. (2002). Improved HPLC Method for the Determination of Curcumin, Demethoxycurcumin, and Bisdemethoxycurcumin. J. Agric. Food Chem., 50(13), 3668–3672.
22. Jadhav, B. K., & Mahadik, K. R. (2007). Development and validation of Improved Reverse Phase HPLC method for simultaneous determination of curcumin, demethoxycurcumin, andbisdemethoxycurcumin. Chromatographia, 65, 483-488.
23. ShanmugamRamaswamy et al. (2014). Development and validation of simultaneous estimation method for curcumin and piperine by RP-UFLC. Pak. J. Pharm. Sci., 27(4), 901-906.
24. Nagappan, K. V., Meyyanathan, S. N., Raja Rajinikanth, B., & Kannan, E. (2009). A Liquid Chromatography Method for the Simultaneous Determination of Curcumin and Piperine in Food Products Using Diode Array Detection. Asian Journal of Research in Chemistry, 2(2), 115-118.
25. Taylor, S. J., & Macdowell, I. J. (1992). Determination of Curcuminoid pigments in Turmeric by Reverse Phase High Performance Liquid Chromatography. Chromatographia, 34, 73-79.
26. Ying, X., Jianga, Z. H, & Zhoua, H. (2007). Combinative method using HPLC quantitative and qualitative analyses for quality consistency assessment of a herbal medicinal preparation. Journal of Pharmaceutical and Biomedical Analysis. 43(1), 204-212.
27. Ramshankar, Y. V., & Suresh, S. (2009). A Sensitive Reversed Phase HPLC Method for the Determination of Curcumin. Phcog Magazine, 5(17), 71-74.
28. Moorthi, C., Kumar, C. S., Mohan, S., & Krishnan, K., & Kathiresan, K. (2013). Application of validated RP-HPLC-PDA method for the simultaneous estimation of curcumin and piperine inEudragit E 100 nanoparticles. Journal of Pharmacy Research, 7, 224-229.
29. Salunkhe, V. R., & Patil, S. J. (2010). UV spectrophotometric and HPLC method development of Quercetin and curcumin in polyherbal churna and its validation. International Journal of Pharmaceutical and Phytopharmacological Research, 1-16.
30. WisutWichitnithad, et al. (2009). A simple isocratic HPLC method for the simultaneous determination of curcuminoids in commercial turmeric extracts. Phytochemical Analysis, 20(4), 314–319.
31. Chittora, N., & Kishore et al. (2010). Stability-indicating RP-HPLC determination of Curcumin in Vicco Turmeric cream and Haridrakhandchurna. Phcog Journal, 2(6), 90-101.
32. Kulkarni, S. J., Maske, K. N., Budre, M. P., & Mahajan, R. P. (2012). Extraction & Purification of curcuminoids from turmeric. IJPPT, 1(2), 81-84.
33. SharadSrivasta. (2009). A HPTLC Method for chemotaxonomic evaluation of some curcuma species and their commercial samples. Journal of Scientific and Industrial Research, 68, 876-880.
34. Reshma, V. L., Gandhi, S. V. (2013). Comparison of Curcuma caesiaRoxb. with other Commonly Used Curcuma Species by HPTLC. Journal of Pharmacognosy and Phytochemistry, 2(4), 126-131.
35. Chavan, A. K., Nirmal, S. A. & Pattan, S. R. (2015). Development and Validation of HPTLC Method to detect Curcumin and Gallic Acid in Polyherbal Microencapsulated Formulation. Journal of Liquid Chromatography & Related Technologies, 38(12), 1213-1217.
36. JothivenkatachalamKandasamy. (2013). Validated method for estimation of curcumin from different varieties of curcuma longa. Int J Pharm Bio. Sci, 4(1), 1004–1010.
37. Ashraf, K. (2012). Validated HPTLC analysis method for quantification of variability in content of curcumin in Curcuma longa L (turmeric). collected from different geographical region of India. An pacific Journal of Tropical Biomedicine, 2(2), 584-588.
38. ArunavaGantait, Barman, T., & Mukherjee, P. K. (2011). Validated method for estimation of curcumin in turmeric powder. Indian Journal of Traditional Knowledge, 10(2), 247-250.
39. Sonawane, S. D., Nirmal, S. A., Patil, A. N., & Pattan, S. R. (2011). Development and validation of HPTLC method to detect Curcumin and Gallic acid in polyherbal formulation. Journal of Liquid Chromatography & Related Technologies. 34(20), 2664-2673.
40. VijaylataPathania, Gupta, A., & Singh, B. (2006). Improved HPTLC Method for Determination of Curcuminoids from Curcuma longa. Journal of Liquid Chromatography & Related Technologies, 29(6), 877-887.
41. Bele, A. A., Jadhav, V. M., & Kadam, V. J. (2011). Development and Validation of HPTLC Method for Estimation of Curcumin, Ellagic acid in Gel Formulation. International Journal of Chemical and Analytical Science. 2(6), 1-11.
42. Dixit, S., Khanna, S. K, & Mukul, D. (2008). A Simple 2-Directional High-Performance Thin-Layer Chromatographic Method for the Simultaneous Determination of Curcumin, Metanil Yellow, and Sudan Dyes in Turmeric, Chili, and Curry Powders. Journal of AOAC International, 91(6), 1387-1396.
43. Vyas, N., Gamit, K., Khan, M. Y., Panchal, S. & Pundarikakshudu, K. (2011). Simultaneous Estimation of Curcumin and Piperine in Their Crude Powder Mixture and Ayurvedic Formulation Using High Performance Thin Layer Chromatography. IJRPBS, 2(1), 231-236.
44. JayantVerma, A. J. (2007). Rapid HPTLC method for identification and quantification of curcumin, piperine and thymol in an ayurvedic formulation. Journal of Planar Chromatography, 19(111), 398-404.
45. Vaykole, A. M., Nirmal, S. A., Jadhav, R. S., & Pattan, S. R. (2014). Development and validation of HPTLC method to detect curcumin, piperine, and boswellic acid in polyherbal transdermal patch. Journal of Liquid Chromatography & Related Technologies, 37(3), 367-378.
46. Paramasivam, M., Poi, R., Banerjee, H., & Bandyopadhyay, A. (2009). High-performance thin layer chromatographic method for quantitative determination of curcuminoids in Curcuma longagermplasm. Food Chemistry, 113(2), 640-644.
47. Sheikh, S., Asghar, S., & Ahmad, S. (2013). Development of HPTLC Method and Its Validation for the Estimation of Curcuminoids from Polyherbal Mouth Ulcer Gel Formulation. IOSR Journal of Pharmacy, 3(1), 29-34.
48. Paramasivam, M., Aktar, W., Poi, R., Banerjee, H., & Bandyopadhyay, A. (2008). Occurrence of curcuminoids in Curcuma longa , A quality standardization by HPTLC. A journal of the Bangladesh Pharmacological Society, 3, 55-58.
49. Thakker, V. Y., Shah, V. N., Shah, U. D., & Suthar, M. P. (2011). Simultaneous estimation of Gallic acid, Curcuminand Quercetin by HPTLC method. Journal of Advanced Pharmacy Education & Research, 1, 70-80.
50. Ansari, M. J., Ahmad, S., Kohli, K., Ali, J., & Khar, V. Y. (2005). Stability-indicating HPTLC determination of curcumin in bulk drug and pharmaceutical formulations. Journal of Pharmaceutical and Biomedical Analysis, 39(1-2), 132-138.
51. Kekre, V.A., Walode, S. G. (2012). Validated HPTLC method for estimation of curcumin content in dietary supplement formulation. IJPSR, 3(10), 3796-3800.
52. SayyadaKhatoon. (2014). Standardization of an Ayurvedic Formulation- Kalyanavleha and estimation of curcumin using HPTLC. Indian Journal of Traditional Knowledge. 13(3), 535-542.
53. Khan, S., Makhija, I. K., Khamar, D., & Rani, S. (2010). Development and standardization of turmeric cream by HPTLC. IJBAR, 1(4), 109-116.
54. PatilSnehal, J., & Salunkhe, V. R. (2012). Simultaneous estimation of Curcumin and Quercetin in Ayurvedic Proprietary Medicine by UV Spectrophotometry. IJRAP, 3(2), 267-271.
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