Micellar Studies of Local Anticonvulsant Gabapentin in Aqueous Electrolyte Solution
More details
Hide details
Department of Chemistry, Punjabi University, Patiala-147002, India
Ashok Kumar Malik   

Department of Chemistry, Punjabi University, Patiala-147002, India
Online publish date: 2007-06-15
Publish date: 2007-06-15
Eurasian J Anal Chem 2007;2(2):93–100
Specific conductivity of aqueous electrolyte solution of anticonvulsant gabapentin (2-[1-(aminomethyl)cyclohexyl]ethanoicacid) has been determined in the temperature range of 303-338 K. The critical micelle concentrations (cmc), ionization degree (α) and the counterion binding of the micelle (β), were estimated from the dependence of specific conductivity on concentration. Thermodynamic parameters, such as standard Gibbs free energy (ΔG°), enthalpy (ΔH°) and entropy (ΔS°) of micellization, were estimated by the mass action model.
Levendoglu F, Ogun C O, Ozerbil O (2004) Gabapentin is a first line drug for the treatment of neuropathic pain in spinal cord injury. Spine 29 (7): 743-751.
Singh D, Kennedy D H (2003) The use of gabapentin for the treatment of postherpetic neuralgia. Clin Ther. 25 (3): 852-889.
Werner M U, Perkins F M, Holte K, Pedersen J L, Kehlet H (2001) Effects of gabapentin in acute inflammatory pain in humans. Reg Anesth Pain Med. 26: 322-328.
Taylor CP (1998) Mechanism of action of Gabapentin. Drugs Today 34: 3-11.
Oremusova J, Greksakova O, Peterek K (2000). Thermodynamics of Hexadecylpyridinium bromide in aqueous and alcoholic (C1-C4) solutions. Czechoslovak Chemical Communication 65(9): 1419-1437.
Akbas H, Kartal C (2006) Conductometric studies of Hexadecyltrimethylammonium bromide in aqueous solutions of ethanol and ethylene glycol. Colloid Journal 68(2): 125- 130.
Andrimainty F, Cizmaric J (2004) Micellization of local anaesthetic Heptacanium chloride in aqueous electrolyte solution. Study of local anaesthetics. Acta Facult. Pharm. Univ. Comenianae 167: 38-44.
Andrimainty F, Cizmaric J (2003) Thermodynamic study of local anaesthetics based on heptacainium chloride derivatives. Study of local anaesthetics. Part 163. Pharmazie 58: 440-441.
Lee D J (1995) Enthalpy-entropy compensation in ionic micelle information. Colloid Polym. Sci. 273: 539-543.
Dominguez A, Fernandez A, Gonzalez N, Iglesias L, Montenegro J (1997) Determination of critical micelle concentration of some surfactants by three techniques. J. Chem. Educ. 74: 1227-1231.
Vojtekova M, Kopecky F, Greksakova O, Oremusova J (1994) Effect of addition of KX type electrolytes and temperature on the critical micellar concentrations of 1- cetylpyridinium and carbethopendecinium bromides. Czechoslovak Chemical Communication 59(1): 99-105.
Galan J J, Gonzalez-Perez A, Rodríguez J R (2003) Micellization of dodecyldimethylethylammonium bromide in aqueous solution. Journal of Thermal Analysis and Calorimetry 72(2): 465-470.
La Mesa C (1989) The temperature-dependence of critical micellar concentrations. Colloid Surf. 35: 329-335.
La Mesa C (1990) Dependence of critical micelle concentration on intesive variables: A Reduced variable analysis. J.Phys.Chem. 94: 323-326.
Sugihara G, Hisatomi M (1999) Enthalpy-entropy compensation phenomenon observed for different surfactants in aqueous solution. J. Colloid Interf. Sci., 219: 31-36.
Lee D J, Huang W H (1996) Enthalpy-entropy compensation in micellization of sodium dodecyl sulphate in water/methanol, water/ethylene glycol and water/glycerol binary mixtures.Colloid & Polymer Science. 274(2): 160-165.