Naproxen Selective Membrane Sensor based on Molecularly Imprinted Polymer and Its Application to Pharmaceutical Analysis
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Publish date: 2019-05-23
Eurasian J Anal Chem 2019;14(2):emEJAC191034
Liquid electrodes of polymers imprinted with naproxen(NPX)was constructed using precipitation polymerization. The molecularly imprinted (MIP) and non imprinted (NIP) polymers were synthesized using NPX as a template. In the polymerization process, acrylamide (AM) was used as monomer ethylene glycol dimethacrylate (EGDMA) as a cross-linker and benzoyl peroxide (BPO) as an initiator. The molecularly imprinted membranes and the non-imprinted membranes were prepared using acetophenone(AOPH) and di octylphathalate(DOP)as plasticizers in PVC matrix. The slopes and detection limits of the liquid electrodes ranged from -19.4 – -21.37 mV/decade and 4.0 x 10-5 – 3.0 x 10-5 M, respectively and their response time was about 1 minute. The Liquid electrodes were filled with 0. 1 M standard solution of drug and their response was stable in a pH range from 1.0 to 11.0 and with good selectivity for over several species. The developed electrodes were successfully applied for the analyte determination in preparation pharmaceutical sample without any time consuming pretreatment steps.