Novel Reagent for the Spectrophotometric Determination of Ranitidine Hydrochloride
 
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Department of Post Graduate Studies and Research in Chemistry, Mangalore University, Mangalagangothri 574 199, India
CORRESPONDING AUTHOR
Badiadka Narayana   

Department of Post Graduate Studies and Research in Chemistry, Mangalore University, Mangalagangothri 574 199, India
Publication date: 2017-10-30
 
Eurasian J Anal Chem 2010;5(2):170–176
 
KEYWORDS
ABSTRACT
A simple and sensitive method is presented for the determination of ranitidine hydrochloride (RNH). The method is based on the reaction of RNH with sodium periodate in acidic medium to liberate iodine. The liberated iodine then bleaches the dye crystal violet (CV). The dye shows absorption maximum at 600nm. The calibration graph is found to be linear over the range 400-500 µg mL-1. The molar absorptivity and Sandell’s sensitivity values are found to be 1.9858×103 Lmol-1cm-1 and 0.1767 µg cm-2 respectively. The method is successfully applied for the determination of ranitidine hydrochloride in pharmaceutical preparations.
 
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