Preventive Effect of Mosinone-A on Immunhistochemical Expression of VEGF Marker during 7, 12-dimethylbenz (a) Anthracene Induced Hamster Buccal Pouch Carcinogenesis
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Online publication date: 2017-02-16
Publication date: 2019-12-19
Eurasian J Anal Chem 2017;12(Interdisciplinary Perspective on Sciences 7b):1633–1637
The present study was investigated to evaluate immunohistochemical expression studies in DMBA induced hamster buccal pouch carcinogenesis.Materials and methods: A total number of 40 golden Syrian hamsters were randomized into 4 groups of 10 animals in each. Group I animals were served as untreated control. Groups II and III animals were painted with 0.5% DMBA in liquid paraffin three times per week for 14 weeks on the left buccal pouches. Group III animals were orally administered with Mosinone-A (2 mg kg-1b.wt) starting one week before the exposure to the carcinogen and continued on days alternate to DMBA painting, until the sacrification of the animals. Group IV animals were received Mosinone-A alone throughout the experimental period. Results: Topical application of DMBA for 14 weeks induced buccal pouch carcinomas associated with increased expression of, VEGF, Oral administration of Mosinone-A significantly inhibited the development of HBP carcinomas as revealed by decreased expression of, VEGF, Conclusion: The result of the present study indicates that Mosinone-A can exerts protective effects against DMBA induced buccal pouch carcinogenesis. These findings suggest that Mosinone-A exerts its anticancer properties by inhibiting cell proliferation and inducing differentiation and apoptosis.