RESEARCH PAPER
Rifampicin as a Novel Reagent in Spectrophotometric Assay of Paracetamol
 
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Chemistry, University of Mosul, Iraq
CORRESPONDING AUTHOR
Nabeel Sabeeh Othman Sabeeh Othman   

Chemistry, University of Mosul, AL-Jamea, -----, MOSUL, Iraq
Publish date: 2019-11-06
 
Eurasian J Anal Chem 2019;14(4):emEJAC-00333
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ABSTRACT
Background:
Rifampicin (REF), an antibiotic, is used for the first time to assay paracetamol in bulk sample and in its dosage forms. The method is based on adding a known excess of N-bromosuccinimide oxidant to the p- aminophenol, resulting from acidic hydrolysis of paracetamol. The residual oxidant is allowed to react with a fixed amount of Rifampicin .

Material and methods:
The chemicals used in present investigation are of analytical – reagent grade.

Results:
The method involves four steps .

Conclusions:
The suggested procedure for PAR determination is sensitive , accurate and can be used in determination PAR in different types of formulations without extraction or separation.

eISSN:1306-3057