RESEARCH PAPER
SPECTROPHOTOMETRIC DETERMINATION OF ISONAIZID BY COUPLING-OXIDATIVE IN PHARMACEUTICAL DRUG
 
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CORRESPONDING AUTHOR
Sabreen Shakir Mahmood   

Department of Applied chemistry - College of Applied Science - University of Samarra –Samarra – Iraq.
Publication date: 2019-04-30
 
Eurasian J Anal Chem 2019;14(1):ememEJAC1930
 
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ABSTRACT
Isoniazide is considered to be one of the most important antibiotics for TB bacteria because of its high efficacy, relatively low toxicity and its low price. 1 The drug was discovered by chance when the researcher Chorine proved in 1945 that nicotine amyotene (nicotinamide) has the ability to stop the effectiveness of tuberculosis bacilli. The discovery was not given importance until 1948 when Mckenzie and his group observed the same effect. A study was conducted on the effect of isonicotinic acid similar to nicotine ammide. It was noted that most pyridine derivatives have almost the same ability to stop the effectiveness of tuberculosis bacilli. In 1952, Fox discovered the isoniazid while trying to collect the active substances used to treat tuberculosis.23 Isoniazide is an organic compound with several scientific names:
eISSN:1306-3057