Simultaneous Estimation of Ramipril and Telmisartan in Tablet Dosage Form by Spectrophotometry
 
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1
Department of Pharmaceutical Analysis, MES College of Pharmacy, Sonai, Ahmednagar, India
2
MP Patel College of Pharmacy, Kapadwanj, Gujrat, India
CORRESPONDING AUTHOR
Popat B. Mohite   

Department of Pharmaceutical Analysis, MES College of Pharmacy, Sonai, Ahmednagar, India
Publish date: 2017-10-05
 
Eurasian J Anal Chem 2010;5(1):89–94
KEYWORDS
ABSTRACT
Two simple ,accurate, sensitive and specific methods are described for the simultaneous determination of Ramipril and Telmisartan in binary mixture. The method based on UV-spectrophotometric determination of two drugs, Method A is by using multicomponant method. It involves absorbance measurement at 205.0 nm(λmax of Ramipril) and 291.0 nm (λmax of Telmisartan) in 0.2M H2SO4;. Beer’s law is obeyed in the concentration range of 5-40 μg mL-1 for Ramipril and 2-20 μg mL-1 for Telmisartan. Method B is graphical absorbance method which is based on measurement of absorbance of Ramipril and Telmisartan at 222.0nm (iso-absorptive point of Ramipril and Telmisartan) and 291.0 nm (λmax of Telmisartan) Both these methods have been successively applied to pharmaceutical formulation and were validated according to ICH guidelines.
 
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