RESEARCH PAPER
Synthesis, Characterization and Biological Activity of new Pyran Derivatives of 8-Hydroxyquinoline
 
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Chemistry, Faculty of science, Ibn Tofaïl University, Morocco
2
Biology, Faculty of science, Ibn Tofaïl University, Morocco
CORRESPONDING AUTHOR
Brahim LAKHRISSI   

Chemistry, Faculty of science, Ibn Tofaïl University, 14000, Kenitra, Morocco
Publish date: 2019-02-07
 
Eurasian J Anal Chem 2018;13(6):em
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ABSTRACT
Background:
We have synthesized a new pyran derivatives based on 8-hydroxyquinoline. All the synthesized compounds were identified and were evaluated and screened “in vitro” by the disk diffusion technique against Gram-positive and Gram-negative bacterial strains.

Material and methods:
All substances used in this study have been purchased from Sigma-Aldrich Chemical Company (Spain or France). Melting points were determined on Banc Kofler apparatus and are uncorrected. Infrared spectra were recorded in a FT-IR Nicolet 400D Spectrophotometer using KBr pellets. The recording of Nuclear Magnetic Resonance spectra was performed on a Bruker Advanced 300 WB at 300 MHz for solutions in Me2SO-d6. The elemental composition (Carbon, hydrogen and nitrogen) was determined on a Perkin-Elmer Model 240 CHN Analyzer.

Results:
In this study, the minimum inhibitory concentration (MIC) was determined by the agar diffusion method [42]. The diameters of the zones of inhibition are measured after 24 hours of incubation at 37 °C.

Conclusions:
In summary, we have described the synthesis and characterization a series of a new pyran derivatives based on 8-hydroxyquinoline. From the screening results, we conclude that the antibacterial activity of the synthesized compounds clearly indicates that the nature of the substituent group (R) on the benzene ring significantly affects the "in vitro" antibacterial activity.

eISSN:1306-3057