Synthesis & Characterization of Heterocyclic Amide Derivative via Ugi Reaction
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College of Basic Education, Sumer University, Thi-Qar, IRAQ
Publication date: 2018-11-06
Eurasian J Anal Chem 2018;13(5):em70
Synthesis of heterocyclic amid derivative (cyclohexanecarbox-amide) by the reacting four-compound [Formaldehyde], [N-(phenethyl)formamide], [Cyclohexanecarboxylic acid], and [Creatinine] as amine source. This reaction is practical extension of (Ugi reaction). The derivatives have been performed with other catalytic agents under temp (-10°C) and the organic synthesis was monitories by TLC [thin layer chromatography] and the formation of final compound proofed by Nuclear Magnetic Resonance Spectra [1HNMR] [13CNMR] BRUKER (500MHz, CDL3), (125MHz, CDL3 and Infra-Red spectra [FT-IR] (shimadzu).
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