Synthesis, characterization and evaluation biological activity of some new Ethyl-2-amino benzothiazole -6-carboxylate derivatives
 
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1
College of Science, Tikrit University, Tikrit, IRAQ.
2
College of pharmacy, Tikrit University, Tikrit, IRAQ.
3
College of Basic Education /Shirqat, Tikrit University, Tikrit, IRAQ.
Online publication date: 2018-06-26
Publication date: 2018-06-26
 
Eurasian J Anal Chem 2018;13(4):emEJAC04329
 
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ABSTRACT
In the current study aimed to investigate a number of heterocyclic compounds 4-amino benzoate (procaine) (A1), where the ester was synthesized by esterification of 4-amino benzoic acid with ethanol. Then, this compound was treated with potassium thiocyanate, followed by oxidative cyclization of the produced thiourea with bromine solution to afford ethyl-2-aminobenzothiazole-6-carboxylate (A2). The produced compound was further treated with some substituted benzaldehyde yielding the Schiff bases (A3a-d). Compound (A2) was also treated with acetic anhydride giving the corresponding N-(ethyl-2-amino benzo thiazolyl-6-carboxylate acetamide (A4). Compound (A4) was allowed to react with hydrazine hydrate afforded 2- benzothiazolyl-6- hydrazido acetamide (A5),which was then condensed with substituted aromatic aldehydes affording 6-[(arylidine hydrazino)-carbonyl]-2-acetamidobenzothiazole as a final product (A6a-d). All the synthesized compounds were characterized by the Infrared (FT-IR) technology. Some of the studied samples were checked by either their elemental analysis, (CHNS), 1H-NMR method, and biological evaluations antibacterial activities for some of the synthesized imides were evaluated against four types of bacteria and in addition to systematic identification of some actives functional groups in these compounds.
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