Voltammetric and Spectrophotometric Studies on the Inclusion Complex of Glipizide with β-cyclodextrin
 
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Department of Chemistry, Faculty of Science (Dumyat), Mansoura University; 34517 Dumyat, Egypt
CORRESPONDING AUTHOR
Abd-Elgawad M. Radi   

Department of Chemistry, Faculty of Science (Dumyat), Mansoura University; 34517 Dumyat, Egypt
Publish date: 2017-10-14
 
Eurasian J Anal Chem 2011;6(1):13–21
KEYWORDS
ABSTRACT
The formation of an inclusion complex of hypoglycaemic drug, glipizide with β-cyclodextrin has been investigated by cyclic, differential pulse voltammetry and UV-vis spectrophotometry. The formation constants of the complex were determined using differential pulse voltammetry and UV-vis spectrophotometry, respectively. For comparative purpose, we have also applied phase solubility study with spectrophotometric detection obtaining formation constant value of 620 M-1. The phase solubility profile was classified as AL–type, indicating the formation of 1:1 stoichiometric inclusion complex of glipizide with β-cyclodextrin.
 
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