Voltammetric behaviour of esomeprazole at screen printed carbon electrode and its determination in capsule dosage form
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Department of Chemistry, Faculty of Science, Dumyat University, Dumyat 34517, Egypt
Abd-Elgawad Radi   

Department of Chemistry, Faculty of Science, Dumyat University, Dumyat 34517, Egypt
Publication date: 2017-10-05
Eurasian J Anal Chem 2014;9(2):92–101
The anodic voltammetric behavior of esomeprazole (ESO) was explored at screen printed carbon electrode (SPCE) in phosphate buffer (PB) solutions over the pH range (2.0–11.0) using cyclic and differential-pulse voltammetry (CV; DPV). The oxidation of ESO was shown to be irreversible and diffusion-adsorption controlled driven process. Under optimized conditions, the DPV peak currents were in a linear relationship to ESO concentrations in the range of 1.0×10-6-1.0×10-4 M with a detection limit of 3.5×10-8 M. The DPV was successfully employed for the determination of ESO in capsules. The results were compared with those obtained by the spectrophotometric method. No difference was found statistically. The voltammetric procedure was successfully also applied for rapid analysis of ESO in stability studies without interference from the degradation products.
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