Electro Oxidation and Determination of Estriol Using a Surfactant Modified Nanotube Paste Electrode

J.G. Manjunatha, Gururaj Kudur Jayaprakash

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Electrochemical Sensor, Cyclic Voltammetry, Estriol, Detection Limit


The electrocatalytic oxidation of Estriol (ET) has been studied by surfactant modified nanotube paste electrode. The sensor was prepared using carbon nanotubes and silicone oil, Carbon nanotube paste electrode (CNTPE) modified with Sodium dodecyl sulfate (SDS) surfactant, the modified electrode highly sensitive for the determination of ET. Cyclic voltammetry (CV) and differential voltammetry (DPV) techniques were used to investigate the ET. A enrich improvement in the microscopic area of the electrode produced in a increase of the peak current of ET oxidation. CV has been used as a electrochemical sensitive analytical method for the detection of small amounts of ET, Two linear ranges have been procured for the ET concentration between the ranges of 6.0 × 10−6 to 2.0 ×10−5 and 2.5 × 10−5 to 1.5 × 10−4 M ET. The detection limit of this electrode is 3.2×10−7 M and the quantification limit is 10×10−7 M. This sensor has a remarkably good sensitivity for the ET determination in the presence of real samples. The recovery for the ET detection in clinical sample was obtained as 97.2-102 % with a good RSD of 4.2%, (on the basis of 5 repeated determinations). These good qualities make the fabricated sensor suitable for the experiments of the trace amounts of ET in pharmaceutical and clinical preparations.