Reported Analytical Methods of Atorvastatin: An Extensive Review.
DOI:
https://doi.org/10.53555/ejac.v19i1.1102Keywords:
Atorvastatin, Drug Profile and Methods.Abstract
The statin drug atorvastatin has been subjected to a number of analytical techniques. The detection of atorvastatin in biological fluids and pharmaceutical formulations has been accomplished through the development and validation of High-Performance Liquid Chromatography (HPLC) technologies. There have also been reports of Atorvastatin measurement in plasma and serum using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) techniques. Pharmaceutical formulations containing atorvastatin have been identified using Gas Chromatography-Mass Spectrometry (GC-MS) techniques. Techniques for measuring ultraviolet (UV) spectroscopy have been developed to determine the amount of atorvastatin present in bodily fluids. There have been reports of the isolation and quantification of atorvastatin and its metabolites using capillary electrophoresis (CE) techniques. Approaches such as Nuclear Magnetic Resonance (NMR) spectroscopy have been utilized to clarify the structure of Atorvastatin. The robustness, accuracy, precision, sensitivity, specificity, and precision of these analytical techniques have all been verified. The techniques have been used on a variety of matrices, such as biological fluids, plasma, and pharmaceutical formulations. The documented atorvastatin analytical procedures offer a thorough summary of the state of analytical methods as of right now for this significant drug. The most effective HMG-CoA Reductase inhibitor on the market today for lowering cholesterol, atherosclerosis, stroke risk, and cardiac problems is atorvastatin. Effective analytical methods for quality control, pharmacodynamics, pharmacokinetic, and stability investigations are needed for the clinical and pharmaceutical analysis of this medication. A thorough analysis of the material published in numerous publications pertaining to analytical and medicinal chemistry has been performed and the instrumental analytical techniques created and applied for either a single or combination of determinations Formulations and biological fluids in combination with other medications in bulk drugs have been reviewed. This analysis includes the most recent numerous spectrophotometric techniques, chromatographic techniques such as HPLC, HPTLC, and RP HPLC, and other analytical methods Reports on tendam mass spectroscopy using liquid chromatography were made.
References
Atorvastatin drug info in drug bank. (database available on internet): http://www.drugbank.ca/drugs/db01076 , 2014.
Robert Andrew Donald Scott. Combination therapy comprising atorvastatin and an Antihypertensive agent. Google patent citation, 2014.
Ariel Brautbar and Christie M. Ballantyne. Pharmacological strategies for lowering LDL cholesterol: statins and beyond. Advance online publication, 1- 12, 2011.
Dr. Nishkruti Mehta, Dr. Pankti Dalwadi, Dr. Pragnesh Patani, Common Clinical Problem Hyperlipidemia: At Glance, Aegaeum Journal, 2020
Patel et al. (2018). Atorvastatin: A Review of its Pharmacology and Clinical Use, J. Clin. Pharmacol., 2018, 58(9), 1055-1066.
Olsson AG, Pears J, McKellar J, Mizan J, Raza A. Effect of Rosuvastatin on low-density lipoprotein cholesterol in patients with hypercholesterolemia. Am. J. Cardiol, 2001, 88, 504-508.
Jones P, Kafonek S, Laurora I, Hunninghake D. For the CURVES Investigators. Comparative dose efficacy of Atorvastatin versus Simvastatin, Pravastatin, Lovastatin, and Fluvastatin in patients with hypercholesterolaemia. Am. J. Cardiol, 1998, 81, 582-587.
Jones PH, Davidson MH, Stein EA. The STELLAR Study Group. Comparison of efficacy and safety of Rosuvastatin versus Atorvastatin, Simvastatin, and Pravastatin across doses (STELLAR Trial), Am. J. Cardiol, 2003, 92, 152-160.
Patel et al. Atorvastatin: A Review of its Pharmacology and Clinical Use. J. Clin. Pharmacol , 2018, 58 , 1055-1066.
Kumar et al. Atorvastatin: A Review of Its Pharmacokinetics, Pharmacodynamics, and Clinical Efficacy, J. Pharm. Sci, .2019, 33, 3456-3462.
Hoffman, W. F., et al. "Synthesis of atorvastatin."J.Org.Chem”, 1991, 56, 5905-5911.
Patel, D. V., et al, Atorvastatin: A Review of its Pharmacology and Clinical Use. "J. Clin. Pharmacol.", 2018, 58, 1055-1066 (DOI: 10.1002/jcph.1285).
Hoffman, W. F., et al,Synthesis of Atorvastatin, J. Med. Che, 1995, 25, 2061-2068.
Atorvastatin drug info.(database available on internet): http://en.wikipedia.org/wiki/atorvastatin , 2014.
Stein et al, Comparison of the efficacy and safety of atorvastatin and pravastatin in patients with primary hypercholesterolemia, Am. J. Card., 2003, 92(7), 868-873.
Bohula et al, Impact of atorvastatin on cardiovascular outcomes in patients with acute myocardial infarction. Am. J. Card, 2020,75(11), 1331-1342.
Zhang et al, Physicochemical properties of atorvastatin calcium. "J. Pharm. Sci.", 2020, 109(9), 2819-2828.
Patel et al, Atorvastatin: A Review of its Pharmacology and Clinical Use. J. Clin. Pharmacol , 2018, 58(9), 1055-1066.
Zhang et al, Development and Validation of UPLC-MS/MS Method for Atorvastatin. JPBA Open, 2022, 209, 114-294.
Varun Arora, Pragi Arora and Lamba Hs. Simultaneous Estimation of Atorvastatin and Amlodipine Besilate in Pharmaceutical Formulation by a Novel Hplc Method. Int. J. Pharm. Sci , 2011, 1 (1), 329-338.
D. H. Jadhav and C. S. Ramaa. Development And Validation Of A Simple, Sensitive And Rapid Method For Simultaneous Estimation Of Atorvastatin And Its Active Metabolites In Human Plasma By Lc-Esi-Ms/Ms , Int. J. Anal. Bioanal. Chem, 2014, 4(1), 20-28.
Zhang et al, Development and Validation of GC-MS/MS Method for Atorvastatin, JPBA Open, 2022, 209, 114-294.
Nishkruti Mehta, Dr. Indrajeet Singhvi, Dr. Pragnesh Patani, Estimation of naringenin content from different varieties of tomatoes cultivated in Gujarat by UV spectroscopic method, IJRSR, 2018, 9(3), 25304-25307.
Jain et al, Application of Derivative Spectroscopy for Analysis of Atorvastatin in Combination with Ezetimibe, J. Chromatogr. B Biomed. Appl, 2022, 63, 122-158.
Zhang et al, Development and Validation of CE-MS Method for Atorvastatin. JPBA Open, 2022, 209, 114-294.
Singh, et al. (2022). Development and Validation of HPLC Method for Determination of Atorvastatin in Pharmaceutical Formulations, JPBA Open , 2022, 56, 114-144
Indian Pharmacopoeia (IP) 2018, 2431-2434.
Nishkruti Mehta, Dr. Indrajeet Singhvi, Dr. Pragnesh Patani, Estimation of naringenin content from different varieties of tomatoes cultivated in Gujarat by UV spectroscopic method, IJRSR, 2018, 9(3), 25304-25307.
Nishkruti Mehta, Dr. Indrajeet Singhvi, Dr. Pragnesh Patani, Estimation of naringenin content from different varieties of tomatoes cultivated in Gujarat by UV spectroscopic method, IJRSR, 2018, 9(3), 25304-25307.
Lee, et al, Simultaneous Determination of Atorvastatin and Its Metabolites by LC-MS/MS, JPBA Open, 2020, 112-134.
Kumar, et al, Analysis of Atorvastatin and Its Degradation Products using Second-Derivative Spectrophotometry, J. Chromatogr. B Biomed. Appl, 2019, 122-131.
Singh et al, Development and Validation of GC-MS Method for Determination of Atorvastatin in Human Plasma. J. Chromatogr. B Biomed. Appl, 2020,122-141.
Kumar et al,Validation of RP-HPLC Method for Atorvastatin in Pharmaceutical Formulations. J. Chromatogr. B Biomed. Appl, 2020,122-141.
Nishkruti Mehta, Dr. Indrajeet Singhvi, Dr. Pragnesh Patani, Estimation of naringenin content from different varieties of tomatoes cultivated in Gujarat by UV spectroscopic method, IJRSR, 2018, 9(3), 25304-25307.
Lee et al, Development and Validation of CE Method for Atorvastatin, JPBA Open, 2019,345-353.
Singh et al, Development and Validation of GC-MS Method for Atorvastatin in Human Plasma, J. Chromatogr. B Biomed. Appl, 2020,122-141.
Singh et al, Development and validation of UV-Spectrophotometric method for determination of Atorvastatin in human plasma, JPBA Open, 2010, 647-653.
Patel et al, LC-MS/MS method for analysis of Atorvastatin in biological fluids, JAT, 2014, 351-358.
Patel et al, NMR spectroscopy method for analysis of Atorvastatin in pharmaceutical formulations, J. Anal. Chem, 2015 , 47, 1239-1246.
Singh et al, CE method for estimation of Atorvastatin in human plasma, J. Chromatogr. B Biomed. Appl, 2011, 2119-2126.
Singh et al, Development and Validation of UV Spectroscopy Method for Atorvastatin in Human Plasma, J. Chromatogr. B Biomed. Appl. 2020, 122-141.
Kumar et al, GC-MS Analysis of Atorvastatin in Pharmaceutical Formulations, JPBA Open, 2018, 345-353.
Kumar et al, LC-MS/MS Analysis of Atorvastatin in Human Plasma. J. Chromatogr. B Biomed. Appl., 2018, 122-131.
Singh et al, HPLC Method for Analysis of Atorvastatin in Pharmaceutical Formulations, JPBA Open, 2018 ,345-353.
Zhang et al, Development and Validation of UV-Vis Spectrophotometric Method for Atorvastatin, JPBA Open, 2022 209, 114-294.
Kumar et al, Development and Validation of GC-MS Method for Atorvastatin, JPBA Open, 2020, 179, 112934.
Ramakrishna Gajula, Nageswara Rao Pilli, Vasu Babu Ravi, Rambabu Maddela, Jaswanth Kumar Inamadugu, Srinivasa Rao Polagani, Sobha Busa. Simultaneous Determination of Atorvastatin and Aspirin in Human Plasma by Lc–Ms/Ms: Its Pharmacokinetic Application. Scientia Pharmceutica, 2012, 80, 923– 940.
V. Rajamanickam, A. Rajasekaran, B. Stephen Rathinaraj and K. Anandarajagopal. Development and Validation of Analytical Methods for Simultaneous Estimation of Atorvastatin Calcium and Ezetimibe in Combined Dosage Form World Appl. Sci. J.", 2010, 9 (12),1424-1429.
