Polyherbal Ointment Formulation and Evaluation for Acne Vulgaris

Abstract

Aim: The aim of this study was to develop and evaluate a new polyherbal ointment, incorporating zinc and silver bhasma along with selected plant extracts, as a potential natural treatment for Acne vulgaris.
Background: Acne vulgaris is a prevalent dermatological condition, primarily affecting teenagers and young adults, often causing physical and psychological distress. Traditional acne treatments, including topical retinoids, benzoyl peroxide, isotretinoin, and antibiotics, are associated with side effects such as dryness and sensitivity. Hence, there is a growing interest in exploring alternative, Ayurvedic, and herbal treatments for acne, which are believed to not only treat the condition but also protect the skin from adverse effects.
Objective: The objective of this study was to develop a polyherbal ointment incorporating zinc and silver bhasma, known for their potential antibacterial properties, and select plant extracts with antimicrobial properties, and evaluate its physicochemical qualities, in vitro drug release, stability, microbiological purity, and efficacy in treating Acne vulgaris.
Method: The study involved the development of a polyherbal ointment using extracts of forest burr, kali musli, and chaff flower in combination with zinc and silver bhasma. The ointment was subjected to various tests and evaluations, including physicochemical analysis, in vitro drug release assessment, stability testing, and microbiological purity evaluation. Additionally, the efficacy of the ointment in treating Acne vulgaris was assessed.
Results: The results of the study indicated that the prepared polyherbal ointment exhibited favorable physicochemical qualities, in vitro drug release profiles, stability over time, and microbiological purity. Moreover, the ointment demonstrated promising effectiveness in the treatment of Acne vulgaris.
Conclusion: In conclusion, the polyherbal ointment developed in this study, containing extracts of forest burr, kali musli, and chaff flower in combination with zinc and silver bhasma, appears to be a potential natural alternative for the treatment of Acne vulgaris. The study's findings suggest that this ointment warrants further investigation and potential future clinical usage as a safe and effective acne treatment option with fewer side effects compared to traditional treatments.
Other: It is important to note that further research, including clinical trials, safety assessments, and long-term efficacy studies, should be conducted to validate the potential of this polyherbal ointment as a mainstream treatment for Acne vulgaris. Additionally, understanding the specific mechanisms by which the ointment acts on acne-causing bacteria and skin inflammation would be valuable for its broader acceptance and utilization in dermatology.