The Multifaceted Health Benefits of Grape Seed Extract: A Comprehensive Review
DOI:
https://doi.org/10.53555/ejac.v19i1.1117Keywords:
Grape seed extract, Vitis vinifera, Antioxidant, AntihypertensiveAbstract
Vitis vinifera L. commonly known as grapes, is a widely cultivated and consumed fruit worldwide. This review article provides a comprehensive overview of the phytochemistry, pharmacological properties, and therapeutic applications of Vitis vinifera. The plant's various parts, including roots, leaves, seeds, juice, and skin, exhibit anti-inflammatory, antioxidant, anti-bacterial, and anti-diabetic activities. Grape seed extract has been shown to possess multifaceted health benefits, including improving cardiovascular health, immune function, and cognitive performance. The extract's proanthocyanidins have been found to regulate LDL cholesterol, inhibit α-amylase and α-glucosidase enzymes, and exhibit anti-hypertensive, antidiabetic, and anti-oxidant effects. This review highlights the potential of Vitis vinifera as a natural remedy for various diseases and emphasizes the need for further research to fully explore its therapeutic potential.
References
Venkitasamy C, Zhao L, Zhang R, Pan Z. Grapes. InIntegrated processing technologies for food and agricultural by-products 2019 Jan 1 (pp. 133-163). Academic Press.
Yang J, Martinson TE, Liu RH. Phytochemical profiles and antioxidant activities of wine grapes. Food Chemistry. 2009 Sep 1;116(1):332-9
Riaz S, Doligez A, Henry RJ, Walker MA. Grape. InFruits and Nuts 2007 (pp. 63-101). Berlin, Heidelberg: Springer Berlin Heidelberg.
Singh J, Kaur H, Kaur R, Garg R, Prasad R, Assouguem A, Kara M, Bahhou J. A Review on the Nutritional Value and Health Benefits of Different Parts of Grape (Vitis vinifera L.). Tropical Journal of Natural Product Research. 2023 Sep 1;7(9).
Esatbeyoglu T, Ewald P, Yasui Y, Yokokawa H, Wagner AE, Matsugo S, Winterhalter P, Rimbach G. Chemical characterization, free radical scavenging, and cellular antioxidant and anti‐inflammatory properties of a stilbenoid‐rich root extract of Vitis vinifera. Oxidative medicine and cellular longevity. 2016;2016(1):8591286.
Goufo P, Singh RK, Cortez I. A reference list of phenolic compounds (including stilbenes) in grapevine (Vitis vinifera L.) roots, woods, canes, stems, and leaves. Antioxidants. 2020 May 8;9(5):398
Yilmaz Y, Göksel Z, Erdoğan SS, Öztürk A, Atak A, Özer C. Antioxidant activity and phenolic content of seed, skin and pulp parts of 22 grape (V itis vinifera L.) cultivars (4 common and 18 registered or candidate for registration). Journal of Food Processing and Preservation. 2015 Dec;39(6):1682-91.
Garavaglia J, Markoski MM, Oliveira A, Marcadenti A. Grape seed oil compounds: Biological and chemical actions for health. Nutrition and metabolic insights. 2016 Jan;9:NMI-S32910.
Williamson G, Carughi A. Polyphenol content and health benefits of raisins. Nutrition Research. 2010 Aug 1;30(8):511-9.
Mandic AI, Đilas SM, Ćetković GS, ČanadanovićBrunet JM, Tumbas VT. Polyphenolic composition and antioxidant activities of grape seed extract. International Journal of Food Properties. 2008 Nov 18;11(4):713-26.
Matthäus B. Virgin grape seed oil: Is it really a nutritional highlight?. European Journal of Lipid Science and Technology. 2008 Jul;110(7):645-50.
Sun BaoShan SB, Spranger MI. Quantitative extraction and analysis of grape and wine proanthocyanidins and stilbenes.
Negro C, Tommasi L, Miceli A. Phenolic compounds and antioxidant activity from red grape marc extracts. Bioresource Technology. 2003 Mar 1;87(1):41-4.
Hong NI, Yaylayan VA, Vijaya Raghavan GS, Paré JJ, Bélanger JM. Microwave-assisted extraction of phenolic compounds from grape seed. Natural product letters. 2001 Aug 1;15(3):197-204
Fiori L, De Faveri D, Casazza AA, Perego P. Grape by-products: extraction of polyphenolic compounds using supercritical CO2 and liquid organic solvent–a preliminary investigation Subproductos de la uva: extracción de compuestos polifenólicos usando CO2 supercrítico y disolventes orgánicos líquidos–una investigación preliminar. Cyta-Journal of Food. 2009 Nov 1;7(3):163-71.
Ju Z, Howard LR. Subcritical water and sulfured water extraction of anthocyanins and other phenolics from dried red grape skin. Journal of Food Science. 2005 May;70(4):S270-6.
Ghafoor K, Choi YH, Jeon JY, Jo IH. Optimization of ultrasound-assisted extraction of phenolic compounds, antioxidants, and anthocyanins from grape (Vitis vinifera) seeds. Journal of agricultural and food chemistry. 2009 Jun 10;57(11):4988-94.
Xia EQ, Deng GF, Guo YJ, Li HB. Biological activities of polyphenols from grapes. International journal of molecular sciences. 2010 Feb 4;11(2):622-46.
Nawaz H, Shi J, Mittal GS, Kakuda Y. Extraction of polyphenols from grape seeds and concentration by ultrafiltration. Separation and Purification Technology. 2006 Mar 1; 48(2):176-81.
https://www.nrcs.usda.gov/wps/portal/nrcs/site/national/home/
Bui, N.H., Nguyen, B.V., Nguyen, T.N.L., Tran, T.T.T., & Mai, H.C. (2022) . Physicochemical properties of seed oil of the Cardinal grape (Vitis vinifera L.) originated in Vietnam. Food research. 2022 Oct; 6(5):161-67.
Varzakas T, Zakynthinos G, Verpoort F. Plant food residues as a source of nutraceuticals and functional foods. Foods. 2016 Dec 10;5(4):88.
Quesada H, Del Bas JM, Pajuelo D, Díaz S, Fernandez-Larrea J, Pinent M, Arola L, Salvadó MJ, Bladé C. Grape seed proanthocyanidins correct dyslipidemia associated with a high-fat diet in rats and repress genes controlling lipogenesis and VLDL assembling in liver. International journal of obesity. 2009 Sep;33(9):1007-12.
Montagut G, Bladé C, Blay M, Fernández-Larrea J, Pujadas G, Salvadó MJ, Arola L, Pinent M, Ardévol A. Effects of a grapeseed procyanidin extract (GSPE) on insulin resistance. The Journal of nutritional biochemistry. 2010 Oct 1;21(10):961-7.
Montagut G, Onnockx S, Vaqué M, Bladé C, Blay M, Fernández-Larrea J, Pujadas G, Salvadó MJ, Arola L, Pirson I, Ardévol A. Oligomers of grape-seed procyanidin extract activate the insulin receptor and key targets of the insulin signaling pathway differently from insulin. The journal of nutritional biochemistry. 2010 Jun 1;21(6):476-81.
Yilmazer-Musa M, Griffith AM, Michels AJ, Schneider E, Frei B. Grape seed and tea extracts and catechin 3-gallates are potent inhibitors of α-amylase and α-glucosidase activity. Journal of agricultural and food chemistry. 2012 ;60(36):8929. 5. Hernandez-Jimenez A, Gomez-Plaza E, Martinez-Cutillas A, Kennedy JA. Grape skin and seed proanthocyanidins from Monastrell× Syrah grapes. Journal of agricultural and food chemistry. 2009 Nov 25;57(22):10803.
Sano A, Uchida R, Saito M, Shioya N, Komori Y, Tho Y, Hashizume N. Beneficial effects of grape seed extract on malondialdehyde-modified LDL. Journal of nutritional science and vitaminology. 2007;53(2):182
Poudel PR, Tamura H, Kataoka I, Mochioka R. Phenolic compounds and antioxidant activities of skins and seeds of five wild grapes and two hybrids native to Japan. Journal of Food Composition and Analysis. 2008 Dec 1;21(8):622-5.
Pastrana-Bonilla E, Akoh CC, Sellappan S, Krewer G. Phenolic content and antioxidant capacity of muscadine grapes. Journal of agricultural and food chemistry. 2003 Aug 27;51(18):5497-503.
Zhang HaiLi ZH, Liu Shuang LS, Li Lan LL, Liu ShiSong LS, Liu ShuQi LS, Mi Jia MJ, Tian Geng TG. The impact of grape seed extract treatment on blood pressure changes: a meta-analysis of 16 randomized controlled trials.
Park E, Edirisinghe I, Choy YY, Waterhouse A, Burton-Freeman B. Effects of grape seed extract beverage on blood pressure and metabolic indices in individuals with pre-hypertension: a randomised, double-blinded, two-arm, parallel, placebo-controlled trial. British Journal of Nutrition. 2016 Jan;115(2):226-38.
Shenoy SF, Keen CL, Kalgaonkar S, Polagruto JA. Effects of grape seed extract consumption on platelet function in postmenopausal women. Thrombosis research. 2007 Jan 1;121(3):431-2.
Sano A, Tokutake S, Seo A. Proanthocyanidin‐rich grape seed extract reduces leg swelling in healthy women during prolonged sitting. Journal of the Science of Food and Agriculture. 2013 Feb;93(3):457-62.
Yahara N, Tofani I, Maki K, Kojima K, Kojima Y, Kimura M. Mechanical assessment of effects of grape seed proanthocyanidins extract on tibial bone diaphysis in rats. Journal of Musculoskeletal and Neuronal Interactions. 2005 Jun 1;5(2):162.
Park JS, Park MK, Oh HJ, Woo YJ, Lim MA, Lee JH, Ju JH, Jung YO, Lee ZH, Park SH, Kim HY. Grape-seed proanthocyanidin extract as suppressors of bone destruction in inflammatory autoimmune arthritis. PLoS One. 2012 Dec 10;7(12):e51377.
Liu Y, Pukala TL, Musgrave IF, Williams DM, Dehle FC, Carver JA. Gallic acid is the major component of grape seed extract that inhibits amyloid fibril formation. Bioorganic & medicinal chemistry letters. 2013 Dec 1;23(23):6336-40.
Calapai G, Bonina F, Bonina A, Rizza L, Mannucci C, Arcoraci V, Laganà G, Alibrandi A, Pollicino C, Inferrera S, Alecci U. A randomized, double-blinded, clinical trial on effects of a Vitis vinifera extract on cognitive function in healthy older adults. Frontiers in pharmacology. 2017 Oct 31;8:776.
Ashtiyani SC, Najafi H, Firouzifar MR, Shafaat O. Grape seed extract for reduction of renal disturbances following reperfusion in rats. Iranian journal of kidney diseases. 2013;7(1):28.
Turki K, Charradi K, Boukhalfa H, Belhaj M, Limam F, Aouani E. Grape seed powder improves renal failure of chronic kidney disease patients. EXCLI journal. 2016;15:424.
Kwatra B. A review on potential properties and therapeutic applications of grape seed extract. World J. Pharm. Res. 2020 Mar 19;9:2519-40.
Wren AF, Cleary M, Frantz C, Melton S, Norris L. 90-day oral toxicity study of a grape seed extract (IH636) in rats. Journal of agricultural and food chemistry. 2002 Mar 27;50(7):2180-92.
Surini S, Mubarak H, Ramadon D. Cosmetic serum containing grape (Vitis vinifera L.) seed extract phytosome: Formulation and in vitro penetration study. Journal of young pharmacists. 2018;10(2s):S51.
RSA SK, Muthulakshmi A. Development & evaluation of poly herbal syrup from some plant extracts with high antioxidant activity.
Sharif A, Akhtar N, Khan MS, Menaa B, Khan BA. Development and optimization of dimethicone-based cream containing muscat hamburg grape extract.
