Ashwagandha & Mental Health: Combatting Depression And Insomnia Naturally
DOI:
https://doi.org/10.53555/ejac.v19i1.1122Keywords:
Ashwagandha, Withania somnifera, Depression, Insomnia, Withanolides, WithaferinAbstract
Medical herbs have been transcribed in ancient texts for their therapeutic uses, Ashwagandha being one such medicinal drug has shown its importance in many neurological diseases and even as immune supplements. Ashwagandha’s use as an antidepressant has significantly increased in the current time as it has proven to be a safer and efficacious drug due to its natural origin. Ashwagandha has its effect as anxiolytics and antidepressants due to Withanolides and Withaferin which are its main chemical constituents. Ashwagandha is a drug with many major therapeutic effects which are yet to be studied and is a very reliable solution for the increasing neurological and psychological disorders.
References
Šantić, Žarko, Nikolina Pravdić, Milenko Bevanda, and Kristina Galić. "The historical use of medicinal plants in traditional and scientific medicine." Psychiatria Danubina. 2017;29: 69-74.
Pan, Si-Yuan, Gerhard Litscher, Si-Hua Gao, Shu-Feng Zhou, Zhi-Ling Yu, Hou-Qi Chen, Shuo-Feng Zhang, Min-Ke Tang, Jian-Ning Sun, and Kam-Ming Ko. "Historical perspective of traditional indigenous medical practices: the current renaissance and conservation of herbal resources." Evidence‐Based Complementary and Alternative Medicine 2014;2: 3-4
Khan, S., and M. Ibrahim. "A systematic review on hepatoprotective potential of grape and polyphenolic compounds: Molecular mechanism and future prospective." Nat. Resour. Hum. Health 2022; 3:196-213.
Ven Murthy, M. R., Prabhakar K Ranjekar, Charles Ramassamy, and Manasi Deshpande. "Scientific basis for the use of Indian ayurvedic medicinal plants in the treatment of neurodegenerative disorders: 1. Ashwagandha." Central Nervous System Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Central Nervous System Agents) 2010;10: 238-246.
Speers, Alex B., Kadine A. Cabey, Amala Soumyanath, and Kirsten M. Wright. "Effects of Withania somnifera (Ashwagandha) on stress and the stress-related neuropsychiatric disorders anxiety, depression, and insomnia." Current neuropharmacology, 2021;19: 8-9
Khan, Maaz Ahmed, Varsha Srivastava, Mariya Kabir, Monalisha Samal, Areeba Insaf, Mohammad Ibrahim, Sultan Zahiruddin, and Sayeed Ahmad. "Development of synergy-based combination for learning and memory using in vitro, in vivo and TLC-MS-bioautographic studies." Frontiers in Pharmacology Volume 12 2021: 6-7.
Brigitta, Bondy. "Pathophysiology of depression and mechanisms of treatment." Dialogues in clinical neuroscience, 2002;4: 7-20.
Miller, Andrew H., and Charles L. Raison. "The role of inflammation in depression: from evolutionary imperative to modern treatment target." Nature reviews immunology, 2016;6: 22-34.
Bhatt, Shvetank, Anantha Naik Nagappa, and Chandragouda R. Patil. "Role of oxidative stress in depression." Drug discovery today, 2020;25: 1270-1276.
Salve, Jaysing, Sucheta Pate, Khokan Debnath, and Deepak Langade. "Adaptogenic and anxiolytic effects of ashwagandha root extract in healthy adults: a double-blind, randomized, placebo-controlled clinical study." Cureus, 2019;11:2-3
Bhat, Javeed Ahmad, Tahira Akther, Rauf Ahmad Najar, Faheem Rasool, and Abid Hamid. "Withania somnifera (L.) Dunal (Ashwagandha); current understanding and future prospect as a potential drug candidate." Frontiers in Pharmacology, 2022;13:12-13
Saleem, Sumaira, Gulzar Muhammad, Muhammad Ajaz Hussain, Muhammad Altaf, and Syed Nasir Abbas Bukhari. "Withania somnifera L.: Insights into the phytochemical profile, therapeutic potential, clinical trials, and future prospective." Iranian journal of basic medical sciences, 2020;23:4-5.
Mikulska, Paulina, Marta Malinowska, Miłosz Ignacyk, Paweł Szustowski, Joanna Nowak, Karolina Pesta, Monika Szeląg et al. "Ashwagandha (Withania somnifera)—Current research on the health-promoting activities: a narrative review." Pharmaceutics, 2023;15: 20-21.
Chandrasekara, Anoma, and Thamilini Josheph Kumar. "Roots and tuber crops as functional foods: a review on phytochemical constituents and their potential health benefits." International journal of food science 2016 ;8: 6-7
Nayak, Shobha, Saurabha Nayak, Binod Kumar Panda, and Sambit Das. "A Clinical Study on management of stress in type-2 diabetes mellitus (Madhumeha) with Ashwagandha (Withania Somnifera)." Ayushdhara, 2015;2:2-3
Kelgane, Sunil B., Jaysing Salve, Prasanthi Sampara, and Khokan Debnath. "Efficacy and tolerability of ashwagandha root extract in the elderly for improvement of general well-being and sleep: a prospective, randomized, double-blind, placebo-controlled study." Cureus, 2020;12:25-26
Yaribeygi, Habib, Yunes Panahi, Hedayat Sahraei, Thomas P. Johnston, and Amirhossein Sahebkar. "The impact of stress on body function: A review." EXCLI journal 2017;16: 5-6
Karasek, Michał. "Dehydroepiandrosterone (DHEA) in postmenopausal women." Menopause Review/Przegląd Menopauzalny, 2005;4: 8-13.
Gopukumar, Kumarpillai, Shefali Thanawala, Venkateswarlu Somepalli, TS Sathyanaryana Rao, Vijaya Bhaskar Thamatam, and Sanjaya Chauhan. "Efficacy and Safety of Ashwagandha Root Extract on Cognitive Functions in Healthy, Stressed Adults: A Randomized, Double‐Blind, Placebo‐Controlled Study." Evidence‐Based Complementary and Alternative Medicine , 2021;5: 1-2
Panossian, A., and G. Wikman. "Evidence based efficacy of adaptogens in fatigue." Planta Medica, 2009;75:5-6
Singh, B., B. K. Chandan, and D. K. Gupta. "Adaptogenic activity of a novel withanolide‐free aqueous fraction from the roots of Withania somnifera Dun.(Part II)." Phytotherapy Research, 2003;17: 531-536.
Ibrahim, Mohammad, Ganesh Pawar, Nazia Khan, Bhushan Gudalwar, Shabina Khan, and Mohd Mazhar. "Therapeutic Effect of Withania somnifera (Ashwagandha) on Depression: A comprehensive review". Natural Resources for Human Health 2024;4:142-151.
Philips, Cyriac Abby, Rizwan Ahamed, Sasidharan Rajesh, Tom George, Meera Mohanan, and Philip Augustine. "Comprehensive review of hepatotoxicity associated with traditional Indian Ayurvedic herbs." World journal of hepatology, 2020;14: 574.
Ireland, Peter J., Timothy Hardy, Alastair D. Burt, and Mhairi C. Donnelly. "Drug-induced hepatocellular injury due to herbal supplement ashwagandha." Journal of the Royal College of Physicians of Edinburgh, 2021;51: 363-366.
Suryawanshi, Gaurav, Mohamed Abdallah, Mary Thomson, Nidhi Desai, Aastha Chauhan, and Nicholas Lim. "Ashwagandha-associated acute liver failure requiring liver transplantation." American journal of therapeutics , 2023;30: 80-83.
Verma, Narsing, Sandeep Kumar Gupta, Shashank Tiwari, and Ashok Kumar Mishra. "Safety of ashwagandha root extract: a randomized, placebo-controlled, study in healthy volunteers." Complementary therapies in medicine 2021;57: 6-7
Kamal, Hawra I., Kunjal Patel, Alexandra Brdak, Jeremy Heffernan, and Naseer Ahmad. "Ashwagandha as a unique cause of thyrotoxicosis presenting with supraventricular tachycardia." Cureus 2022;14:3:2-4.
Połumackanycz, Milena, Aneta Forencewicz, Marek Wesołowski, and Agnieszka Viapiana. "Ashwagandha (Withania somnifera L.)–roślina o udokumentowanych właściwościach prozdrowotnych." Farm Pol, 2020;76: 442-447.
Gupta, Sonu, Ravinder Nath Bansal, Surender Pal Singh Sodhi, Gursimrat Kaur Brar, and M. Molhotra. "Ashwagandha (Withania somnifera)–a herb with versatile medicinal properties empowering human physical and mental health." Journal of Pre-Clinical and Clinical Research, 2021;15: 129-133.
Akhgarjand, Camellia, Farzaneh Asoudeh, Amir Bagheri, Zahra Kalantar, Zahra Vahabi, Sakineh Shab‐bidar, Hamid Rezvani, and Kurosh Djafarian. "Does Ashwagandha supplementation have a beneficial effect on the management of anxiety and stress? A systematic review and meta‐analysis of randomized controlled trials." Phytotherapy Research, 2022;36: 4115-4124.
Savai, Jay, Alice Varghese, Nancy Pandita, and Meena Chintamaneni. "Investigation of CYP3A4 and CYP2D6 interactions of Withania somnifera and Centella asiatica in human liver microsomes." Phytotherapy Research, 2015;29:785-790.
Lopresti, Adrian L., and Stephen J. Smith. "Ashwagandha (Withania somnifera) for the treatment and enhancement of mental and physical conditions: A systematic review of human trials." Journal of Herbal Medicine 2021:28:7-8: 100434.
Clayton, Anita H., Saria El Haddad, Josepha-Pearl Iluonakhamhe, Caridad Ponce Martinez, and Alexandra Elizabeth Schuck. "Sexual dysfunction associated with major depressive disorder and antidepressant treatment." Expert opinion on drug safety 2014:13:1361-1374.
Chandrasekhar, Kartik, Jyoti Kapoor, and Sridhar Anishetty. "A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults." Indian journal of psychological medicine, 2012;34: 255-262.
Candelario, Manuel, Erika Cuellar, Jorge Mauricio Reyes-Ruiz, Narek Darabedian, Zhou Feimeng, Ricardo Miledi, Amelia Russo-Neustadt, and Agenor Limon. "Direct evidence for GABAergic activity of Withania somnifera on mammalian ionotropic GABAA and GABAρ receptors." Journal of ethnopharmacology, 2015;171: 264-272.
Paul, Bharata, Shreya Chakraborty, Utpala Anand, Sarala Dey, Samaira Nandy, Mimosa Ghorai, Suchismita Chatterjee Saha et al. "Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects." Biomedicine & Pharmacotherapy, 2021;143:140-142.
Singh, Narendra, Mohit Bhalla, Prashanti de Jager, and Marilena Gilca. "An overview on ashwagandha: a Rasayana (rejuvenator) of Ayurveda." African journal of traditional, complementary and alternative medicines, 2011;8:4-5
Saha, K., J. Torous, E. Kiciman, and M. De Choudhury. "Understanding side effects of antidepressants: large-scale longitudinal study on social media data. JMIR Ment Health. 2021;8:3-4
Langade, Deepak, Vaishali Thakare, Subodh Kanchi, and Sunil Kelgane. "Clinical evaluation of the pharmacological impact of ashwagandha root extract on sleep in healthy volunteers and insomnia patients: A double-blind, randomized, parallel-group, placebo-controlled study." Journal of ethnopharmacology, 2021;264:12-13.
Majeed, Muhammed, Kalyanam Nagabhushanam, and Lakshmi Mundkur. "A standardized Ashwagandha root extract alleviates stress, anxiety, and improves quality of life in healthy adults by modulating stress hormones: Results from a randomized, double-blind, placebo-controlled study." Medicine, 2023;102:21-22
Joshi, Vinod Kumar, and Apurva Joshi. "Rational use of Ashwagandha in Ayurveda (Traditional Indian Medicine) for health and healing." Journal of Ethnopharmacology, 2021;276: 4-5
Ahmad, Muzamil, and Nawab J. Dar. "Withania somnifera: Ethnobotany, pharmacology, and therapeutic functions." In Sustained energy for enhanced human functions and activity, Academic Press, 2017;12: 137-154
A Dar, Parvaiz, Laishram R Singh, Mohammad A Kamal, and Tanveer A Dar. "Unique medicinal properties of Withania somnifera: Phytochemical constituents and protein component." Current pharmaceutical design, 2016;22: 535-540.
Mandlik, Deepa S., and Ajay G. Namdeo. "Pharmacological evaluation of Ashwagandha highlighting its healthcare claims, safety, and toxicity aspects." Journal of dietary supplements,2021;18: 183-226.
Panossian, Alexander, and Georg Wikman. "Effects of adaptogens on the central nervous system and the molecular mechanisms associated with their stress—protective activity." Pharmaceuticals, 2010;3: 188-224.
Kaur, Parvinder, Sheenu Mathur, Meenakshi Sharma, Manisha Tiwari, K. K. Srivastava, and Ramesh Chandra. "A biologically active constituent of Withania somnifera (ashwagandha) with antistress activity." Indian Journal of Clinical Biochemistry, 2001;16:195-198.
Murthy, Sindgi Vasudeva, Syeda Nishat Fathima, and Rakesh Mote. "Hydroalcoholic extract of ashwagandha improves sleep by modulating GABA/histamine receptors and EEG slow-wave pattern in in vitro-in vivo experimental models." Preventive Nutrition and Food Science, 2022;27:6-8
Abedon, Bruce, B. Auddy, J. Hazra, A. Mitra, and S. Ghosal. "A standardized Withania somnifera extract significantly reduces stress-related parameters in chronically stressed humans: a double-blind, randomized, placebo-controlled study." Jana, 2008;11: 50-56.
Gopukumar, Kumarpillai, Shefali Thanawala, Venkateswarlu Somepalli, TS Sathyanaryana Rao, Vijaya Bhaskar Thamatam, and Sanjaya Chauhan. "Efficacy and Safety of Ashwagandha Root Extract on Cognitive Functions in Healthy, Stressed Adults: A Randomized, Double‐Blind, Placebo‐Controlled Study." Evidence‐Based Complementary and Alternative Medicine 2021;4:8-9.
Mikulska, Paulina, Marta Malinowska, Miłosz Ignacyk, Paweł Szustowski, Joanna Nowak, Karolina Pesta, Monika Szeląg et al. "Ashwagandha (Withania somnifera)—Current research on the health-promoting activities: a narrative review." Pharmaceutics, 2023;15: 20-21.
Lopresti, Adrian L., Stephen J. Smith, Hakeemudin Malvi, and Rahul Kodgule. "An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study." Medicine, 2019;98:37: 15-16.
Chandrasekhar, Kartik, Jyoti Kapoor, and Sridhar Anishetty. "A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults." Indian journal of psychological medicine, 2012;34: 255-262.
Bassareo, Valentina, Simona Porru, Michela Rosas, Roberto Frau, Giuseppe Talani, Enrico Sanna, and Elio Acquas. "New insights on the effects of Withania somnifera on the motivational properties of addictive drugs." In XVII-National Congress of the Italina Neuroscience Society. 2017;4:16-18
