“Impact of post-COVID-19 pandemic on Asthmatic Patients: A Comprehensive Review.”
DOI:
https://doi.org/10.53555/ejac.v19i1.1130Keywords:
COVID-19, Asthma, Phenotype, Inhaled corticosteroid, PolymorphismAbstract
Since its worldwide attack in 2019, Coronavirus has impacted a few parts of patients' lives and represented a critical effect on the medical services framework. Patients with asthma were once assumed to be at a higher risk and severity of SARS-CoV-2 infection. However, emerging research shows that asthma endotypes/phenotypes and comorbidities increase risk stratification in this group. The emergence of additional variations of concerns such as Omicron BA.2, BA.4, and BA.5, as well as the global distribution of COVID-19 vaccinations, have altered the clinical picture of COVID-19. Multisystem inflammatory syndrome in children (MIS-C) can produce severe and diverse illness but has a reduced fatality rate. Long-term COVID-19 symptoms may be caused by disruptions in T cell, B cell, and mast cell immunity, as well as autoantibodies and metabolic reprogramming. Moreover, there is little evidence to support early worries over a possible higher risk of unfavorable outcomes while using asthma medications such biologics and inhaled corticosteroids. Furthermore, ICS has been hypothesized to provide some protection against SARS-CoV-2 infection and the development of severe illness by decreasing the expression of angiotensin converting enzyme-2 and transmembrane protease serine in the lung. As discoveries propose that Th2-high irritation might decrease the gamble of SARS-Cov-2 contamination and illness seriousness as opposed to expanded risk in patients with Th2-low asthma. However, this article has overview about active cases, lifestyle, management and effect of COVID 19 on asthma.
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