“A Thorough Review of Iron Deficiency in Women: Exploring the Diverse Causes, Impacts and Treatment Strategies”
DOI:
https://doi.org/10.53555/ejac.v19i1.1131Keywords:
Iron deficiency, Anemia, Causes, Treatment strategies, Health impactsAbstract
Iron deficiency is the general micronutrient deficiency around the developing world in the current scenario. More than 20% of women are iron deficient in their reproductive years. Approximately 1.97 billion people worldwide are affected by anemia. From which 50-80% of anemia cases are due to iron deficiency. The major risk factors for iron deficiency for women include high menstrual blood loss, abnormal uterine bleeding, increased iron requirement, and insufficient dietary iron intake. This condition can lead to severe health issues, including maternal and fetal damage, decreased work performance, anemia, and many more. Effective management of disease includes oral iron supplements, IV iron formulation, and blood transfusion. Oral iron supplementation is the majorly preferred treatment for most cases. In cases where oral iron supplementation is not enough or in the presence of severe anemia, IV iron supplementation is the preferred alternative treatment method. Timely diagnosis and suitable treatment are important for managing the iron balance and preventing women from further complications. The objective of this article is to provide a comprehensive review of major causes of iron deficiency and available treatment options. By reviewing the current available strategies and identifying the major causes, this article offers recommendations for effective management of iron deficiency.
References
Percy L, Mansour D. “Iron deficiency and iron‐deficiency anaemia in women's health.” The Obstetrician & Gynaecologist. 2017, 19, 55-161.
Pai RD, Chong YS, Clemente-Chua LR, Irwinda R, Huynh TN, Wibowo N, Gamilla MC, Mahdy ZA. “Prevention and management of iron deficiency/iron-deficiency anemia in women: an Asian expert consensus.” Nutrients. 2023, 15, 3125.
Coad J, Pedley K. “Iron deficiency and iron deficiency anemia in women.” Scandinavian journal of clinical and laboratory investigation. 2014, 74, 82-89.
Chouraqui JP. “Dietary approaches to iron deficiency prevention in childhood a critical public health issue.” Nutrients. 2022, 14, 1604.
Bathla S, Arora S. “Prevalence and approaches to manage iron deficiency anemia (IDA).” Critical Reviews in Food Science and Nutrition. 2022, 62, 8815-8828.
Loncar G, Obradovic D, Thiele H, von Haehling S, Lainscak M. “Iron deficiency in heart failure.” ESC heart failure. 2021, 8, 2368-2379.
Benson CS, Shah A, Stanworth SJ, Frise CJ, Spiby H, Lax SJ, Murray J, Klein AA. “The effect of iron deficiency and anaemia on women’s health.” Anaesthesia. 2021, 76, 84-95.
Coad J, Conlon C. “Iron deficiency in women: assessment, causes and consequences.” Current Opinion in Clinical Nutrition & Metabolic Care. 2011, 14, 625-634
Pasricha SR, Tye-Din J, Muckenthaler MU, Swinkels DW. “Iron deficiency.” The Lancet. 2021, 397, 233-248.
Urrechaga E, Izquierdo-Alvarez S, Llorente M, Escanero JF. “Prevalence of iron deficiency in healthy adolescents.” Annals of Nutritional Disorders & Therapy. 2016, 3, 1036.
Dasa F, Abera T. “Factors affecting iron absorption and mitigation mechanisms: a review.” Int. J. Agric. Sci. Food Technol. 2018, 4, 24-30.
Mesias M, Seiquer I, Navarro MP. “Iron nutrition in adolescence.” Critical reviews in food science and nutrition. 2013, 53, 1226-1237.
Wang W, Bourgeois T, Klima J, Berlan ED, Fischer AN, O'Brien SH. “Iron deficiency and fatigue in adolescent females with heavy menstrual bleeding.” Haemophilia. 2013, 19, 225-30.
Garzon S, Cacciato PM, Certelli C, Salvaggio C, Magliarditi M, Rizzo G. “Iron deficiency anemia in pregnancy: Novel approaches for an old problem.” Oman medical journal. 2020, 35, 166.
Munoz M, Gómez-Ramírez S, Bhandari S. “The safety of available treatment options for irondeficiency anemia.” Expert opinion on drug safety. 2018, 17, 149-159.
Fadly D, Angkasa D, Friawan A. “Fortification of ferrous fumarate on tempeh and drinks of Vigna unguiculata (L.) and Phaseolus vulgaris (L.).” Food Research. 2023, 7, 46-51.
Shubham K, Anukiruthika T, Dutta S, Kashyap AV, Moses JA, Anandharamakrishnan C. “Iron deficiency anemia: A comprehensive review on iron absorption, bioavailability and emerging food fortification approaches.” Trends in Food Science & Technology. 2020, 99, 58-75.
Chaudhary A, Kumari M, Vyas S. ‘Strategies to combat Iron Deficiency Anemia among lactating women in India: A Review.” Food and Humanity. 2024, 5, 100253.
Natekar P, Deshmukh C, Limaye D, Ramanathan V, Pawar A. “A micro review of a nutritional public health challenge: iron deficiency anemia in India.” Clinical Epidemiology and Global Health. 2022, 14, 100992.
Lynch SR. “Why nutritional iron deficiency persists as a worldwide problem.” The Journal of nutrition. 2011, 141, 763S-768S.
Briguglio M, Hrelia S, Malaguti M, Lombardi G, Riso P, Porrini M, Perazzo P, Banfi G. “The central role of iron in human nutrition: from folk to contemporary medicine.” Nutrients. 2020, 12, 1761.
Camaschella C. “Iron deficiency.” Blood, The Journal of the American Society of Hematology. 2019, 133, 30-39.
Zimmermann MB, Hurrell RF. “Nutritional iron deficiency.” The lancet. 2007, 370, 511-520.
McClung JP, Murray-Kolb LE. “Iron nutrition and premenopausal women: effects of poor iron status on physical and neuropsychological performance.” Annual review of nutrition. 2013, 33, 271-288.
Means RT. “Iron deficiency and iron deficiency anemia: implications and impact in pregnancy, fetal development, and early childhood parameters.” Nutrients. 2020, 12, 447.
Munro MG. “Heavy menstrual bleeding, iron deficiency, and iron deficiency anemia: Framing the issue.” International Journal of Gynecology & Obstetrics. 2023, 162, 7-13.
Pettit K, Rowley J, Brown N. “Iron deficiency.” Paediatrics and child health. 2011, 21, 339-343.
Toxqui L, Vaquero MP. “Chronic iron deficiency as an emerging risk factor for osteoporosis: a hypothesis.” Nutrients. 2015, 7, 2324-2344.
Cappellini MD, Musallam KM, Taher AT. “Iron deficiency anaemia revisited.” Journal of internal medicine. 2020, 287, 153-170.
Joosten E. “Iron deficiency anemia in older adults: A review.” Geriatrics & gerontology international. 2018, 18, 373-379.
Aspuru K, Villa C, Bermejo F, Herrero P, Lopez SG. “Optimal management of iron deficiency anemia due to poor dietary intake.” International journal of general medicine. 2011, 4, 741-750.
Rohr M, Brandenburg V, Brunner-La Rocca HP. “How to diagnose iron deficiency in chronic disease: A review of current methods and potential marker for the outcome.” European Journal of Medical Research. 2023, 28, 15.
Lopez A, Cacoub P, Macdougall IC, Peyrin-Biroulet L. “Iron deficiency anaemia.” The Lancet. 2016, 387, 907-916.
Burton JK, Yates LC, Whyte L, Fitzsimons E, Stott DJ. “New horizons in iron deficiency anaemia in older adults.” Age and ageing. 2020, 49, 309-318.
Yang J, Li Q, Feng Y, Zeng Y. “Iron deficiency and iron deficiency anemia: Potential risk factors in bone loss.” International Journal of Molecular Sciences. 2023, 24, 6891.
Polin V, Coriat R, Perkins G, Dhooge M, Abitbol V, Leblanc S, Prat F, Chaussade S. “Iron deficiency: from diagnosis to treatment.” Digestive and Liver Disease. 2013, 45, 803-809.
Friedman AJ, Shander A, Martin SR, Calabrese RK, Ashton ME, Lew I, Seid MH, Goodnough LT. “Iron deficiency anemia in women: a practical guide to detection, diagnosis, and treatment.” Obstetrical & Gynecological Survey. 2015, 70, 342-353.
Clark SF. “Iron deficiency anemia.” Nutrition in clinical practice. 2008, 23, 128-141.
Gambling L, Lang C, McArdle HJ. “Fetal regulation of iron transport during pregnancy.” The American journal of clinical nutrition. 2011, 94, S1903-S1907.
Georgieff MK. “Long-term brain and behavioral consequences of early iron deficiency.” Nutrition reviews. 2011, 69, S43-S48.
Auerbach M, Adamson JW. “How we diagnose and treat iron deficiency anemia.” American journal of hematology. 2016, 91, 31-38.
Sun H, Wang Q, Han W, Chen C, Wang T, Zhong J. “Iron deficiency: prevalence, mortality risk, and dietary relationships in general and heart failure populations.” Frontiers in Cardiovascular Medicine. 2024, 11, 1342686.
Isroilovich AE, Isroilovna AZ. “Treatment of pregnant women with iron deficiency and work with patients.” European journal of modern medicine and practice. 2024, 4,1-5.
Talarico V, Giancotti L, Mazza GA, Miniero R, Bertini M. “Iron deficiency anemia in celiac disease.” Nutrients. 2021, 13, 1695.
Umbreit J. “Iron deficiency: a concise review.” American journal of hematology. 2005, 78, 225-231.
Lo JO, Benson AE, Martens KL, Hedges MA, McMurry HS, DeLoughery T, Aslan JE, Shatzel JJ. “The role of oral iron in the treatment of adults with iron deficiency.” European journal of haematology. 2023, 110, 123-130.
Drozd M, Jankowska EA, Banasiak W, Ponikowski P. “Iron therapy in patients with heart failure and iron deficiency: review of iron preparations for practitioners.” American Journal of Cardiovascular Drugs. 2017, 17, 183-201.
Stoffel NU, von Siebenthal HK, Moretti D, Zimmermann MB. “Oral iron supplementation in iron-deficient women: How much and how often?” Molecular aspects of medicine. 2020, 75, 100865.
Savarese G, von Haehling S, Butler J, Cleland JG, Ponikowski P, Anker SD. “Iron deficiency and cardiovascular disease.” European Heart Journal. 2023, 44, 14-27.
Ledwidge M, Ryan F, Seoighe A, Santos-Martinez MJ, Ryan C, Gilmer JG. “Management of iron deficiency in women of childbearing age with oral iron intolerance: a prospective, randomised, controlled trial of three doses of an iron-whey-protein formulation: Prospective Randomised study of women of Childbearing age with gastrointestinal Intolerance to Oral iron.” International Journal of Clinical Pharmacy. 2024, 46, 390-400.
Gomez-Ramirez S, Bisbe E, Shander A, Spahn DR, Munoz M. “Management of perioperative iron deficiency anemia”. Acta haematologica. 2019, 142, 21-29.
Jbireal JM, Azab AE, Hasan SM. “Iron Deficiency Anemia: Insights into the Prevalence, Causes, Iron Metabolism, Manifestations, Diagnosis, and Treatment.” Clinical Research in Hematology 2020, 3,1-8.
Kalra PA, Bhandari S. “Efficacy and safety of iron isomaltoside in the management of patients with iron deficiency anemia.” International journal of nephrology and renovascular disease. 2016, 9, 53-64.
