A Prospective Randomized Comparative Study Of The Effect Of Single Preemptive Dose Of Oral Pregabalin Versus Oral Gabapentin On Sensory And Motor Blockade On Sub Arachnoid Block In Patients Undergoing Elective Infra Umbilical Surgeries
DOI:
https://doi.org/10.53555/ejac.v20i1.1159Keywords:
.Abstract
Introduction: Acute pain accompanies almost all surgical procedures. The goal of postoperative pain relief is to achieve optimal analgesia, facilitating a quick return to normal physiological function. Gabapentinoids have been shown to reduce post-operative pain and opioid analgesic requirement in various studies involving general anaesthesia.
Objectives: This study was being done to evaluate and compare the efficacy of single preemptive dose of oral Pregabalin (300mg) versus oral Gabapentin (1200mg) on the time of onset and quality of sensory and motor blockade and on the duration of postoperative analgesia in patients undergoing elective infra umbilical surgeries under Sub Arachnoid block.
Methodology: This prospective randomized comparative study was conducted on 90 subjects. Subjects were divided into 3 groups, and the sensory and motor blockade were assessed.
Results: The time taken to achieve a sensory level of T6 was 7.4±0.6min in group G, 7.3±0.7min in group P and 7.4±0.6 min in group C, with no statistically significant difference between the groups. Motor blockade characteristics was compared and there was no statistically significant difference (p value=0.12).
Conclusion: Preemptive oral Pregabalin and Gabapentin provide longer duration of post-operative analgesia and reduced requirement of rescue analgesics in patients undergoing infra umbilical surgeries under sub arachnoid block. Preemptive oral pregabalin and gabapentin also prolong the period of sensory and motor blockade.
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