Formulation and Evaluation of Gliclazide Solid Dispersion for Solubility and Dissolution Enhancement
DOI:
https://doi.org/10.53555/ejac.v13i1.1196Keywords:
Solid dispersion, solvent method, PEG 6000, Gliclazide, PVP K-30.Abstract
Gliclazide is a type of medication used to treat non-insulin-dependent diabetes. It belongs to a group of drugs called sulfonylureas. Gliclazide isn’t very well absorbed by the body because it doesn’t dissolve easily in water. In this study, scientists made a special mix called solid dispersions of gliclazide using a solvent method. They used different ratios of the drug to the mixers, which were 1:9, 2:8, 3:7, 4:6, and 5:5. The mixers used were polyvinyl pyrrolidone K-30 and polyethylene glycol 6000, and they were used in a 1:1 ratio. The properties of the mix were checked using various tests like DSC, FTIR, XRD and tests for how well the drug dissolves and how soluble it is. The SEM results showed that gliclazide was spread out well and existed in an amorphous form in the mix. The FTIR results showed that there was no chemical bonding between gliclazide and the mixers. The DSC test showed that the melting point of gliclazide was lower in the mix. The XRD test showed that the mix had less crystalline structure than pure gliclazide. The mix also made the drug dissolve and become more soluble than pure gliclazide, and this difference was statistically significant (F < 0. 05).
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