A simple, economic, accurate reverse phase isocratic RP-HPLC method has been developed for the quatitation of diacerein in tablet dosage form. The quantitation was carried out using Zorbax CN column. The mobile phase was ammonium acetate buffer (pH adjusted to 3.5) : Acetonitrile [53:47]. The LOD and LOQ are found to be 3.952µg/ml and 11.97µg/ml respectively. The flow rate was 1ml/min with UV detection at 254nm.The method has been validated and proved to be accurate, precise, linear, rugged, robust, simple and rapid. The calibration curve was linear in the concentration range 25-150µg/ml with coefficient of correlation 0.99942. The percentage recovery of diacerein was found to be 101.60%.The method is useful in the quality for the estimation of diacerein in tablet dosage form.