A  sensitive,  selective,  precise  and  stability  indicating  high-performance  thin-layer

chromatographic  method  of  analysis  of  Amlodipine besylate and Nebivolol hydrochloride both  as  a  bulk  drug  and  in formulations  containing these two in combination was  developed  and  validated.  The  method  employed  TLC  aluminium  plates precoated  with  silica  gel  60F₂₅₄  as  the  stationary  phase.  The solvent system consisted of Ethyl acetate: Methanol: Dilute ammonia (8.5:1:1, v/v/v). This system was found to give compact spots for Amlodipine besylate (R_f 0.40± 0.01) and Nebivolol hydrochloride (R_f 0.60 ± 0.02). Amlodipine besylate and Nebivolol hydrochloride were individually subjected to stress degradation conditions like oxidation, dry heat treatment, photo degradation and hydrolysis under different pH. The peaks of products formed during stress degradation studies were well resolved from the bulk drug peak with significantly different Rf values. Densitometric analysis of Amlodipine besylate and Nebivolol hydrochloride was carried out at 240 and 280 nm respectively. The linear regression analysis data showed good linear relationship in the concentration range 500–2000 ng spot ^-1 for both Amlodipine besylate and Nebivolol hydrochloride. The method was validated for linearity, accuracy, specificity, LOD,  LOQ, precision and robustness. The limits of quantitation for Amlodipine besylate and Nebivolol hydrochloride were found to be 313 and 277 ng spot ^-1 respectively. The statistical analysis proved that the method is repeatable and selective for the estimation of the said drugs. As the method could effectively detect the drugs in the presence of their degradation products, it can be employed as a stability indicating one.